Analysis of ABC (D) stratification for screening patients with gastric cancer

Table 1 Characteristics of the patients with gastric cancer in this study

Characteristics		All patients	A	B	C	D
No. of patients		95	10	27	54	4
Age (yr)	Mean (range)	67.9 ± 8.9 (38-83)	69.2 ± 10.0 (48-79)	65.5 ± 9.0 (43-77)	68.4 ± 7.6 (38-83)	70.3 ± 6.9 (63-78)
	Median	69	70.5	67	69.5	70
Sex	Male/female	72/23	5/5	19/8	45/9	3/1
Location	U/M/L	19/42/34	2/6/2	2/14/11	15/22/17	0/0/4
Macroscopic type	Elevated/flat/depressed	51/4/40	5/0/5	12/0/15	31/3/20	3/1/0
Differentiation	Well diff/poorly diff	76/19	8/2	18/9	47/7	3/1

U: Upper thirds of the stomach; M: Middle; L: Lower; Well diff: Well or moderately differentiated adenocarcinoma; Poorly diff: Poorly differentiated adenocarcinoma or signet ring cell carcinoma.

Table 2 Relationship between ABC (D) stratification and endoscopic atrophic border in patients with gastric cancers

	Endoscopic atrophic border
ABC (D) stratification	Non	Closed type	Open type	Total
A: H. pylori (-) PG (-)	1	3	6	10 (10.6%)
B: H. pylori (+) PG (-)	1	7	19	27 (28.4%)
C: H. pylori (+) PG (+)	0	10	44	54 (56.8%)
D: H. pylori (-) PG (+)	0	1	3	4 (4.2%)
Total	2 (2.1%)	21 (22.1%)	72 (75.8%)	95 (100%)

H. pylori: Helicobacter pylori; PG: Pepsinogen; Non: No atrophic change.

Table 3 Summary of 10 patients with gastric cancer in group A and group A’

Case	Stratification	Age (yr)	Sex	Location	Macroscopic type	Differentiation	PG I/PG II levels (ng/mL)	PG I/PG II ratio	Endoscopic findings	PPI prescription	H. pylori eradication therapy
1	A	70	M	U	Borrmann II	Poor	28.5/7.3	3.9	Open type	No	No
2	A'	48	F	M	II c + III	Signet ring cell carcinoma	55.9/8.2	6.8	Closed type	No	Yes
3	A	68	M	M	II a + II c	Well	64.1/11.8	5.4	Open type	No	No
4	A	78	F	L	II c	Well	13.6/4.2	3.2	Open type	No	No
5	A'	67	F	L	II c	Well	46.4/10.8	4.3	Closed type	Yes	No
6	A'	79	F	M	II a + II c	Well	86.2/10.9	7.9	Closed type	Yes	No
7	A'	77	M	M	LST-G	Well	384.9/54.3	7.1	Non	Yes	No
8	A'	77	F	U	II c	Well	17.3/5.2	3.3	Open type	No	Yes
9	A'	57	M	M	II c	Well	36.9/6.8	5.4	Open type	No	Yes
10	A'	71	M	M	II a + II c	Well	38.6/7.9	4.9	Open type	No	Yes

H. pylori: Helicobacter pylori; PG: Pepsinogen; U: Upper thirds of the stomach; M: Middle; L: Lower; PPI: Proton pump inhibitor; Non: No atrophic change.

Table 4 Histological analysis and ABC (D) stratification based on the status of endoscopic atrophic border

	All patients	Well diff	Poorly diff	P value
No. of patients	95	76	19
Male:female	72:23	58:18	14:5	NS
Age (yr, mean ± SD)	67.9 ± 8.9	70.2 ± 5.8	61.4 ± 12.9	< 0.05
ABC (D) stratification
A: H. pylori (-) PG (-)	10 (10.6%)	8 (10.5%)	2 (10.6%)	NS
B: H. pylori (+) PG (-)	27 (28.4%)	18 (23.7%)	9 (47.3%)
C: H. pylori (+) PG (+)	54 (56.8%)	47 (61.8%)	7 (36.8%)
D: H. pylori (-) PG (+)	4 (4.2%)	3 (3.9%)	1 (5.3%)
Endoscopic atrophic border
Non	2 (2.1%)	2 (2.6%)	0 (0%)	NS
Closed type	21 (22.1%)	15 (19.7%)	6 (31.6%)
Open type	72 (75.8%)	59 (77.6%)	13 (68.4%)

H. pylori: Helicobacter pylori; PG: Pepsinogen; Non: No atrophic change; Well diff: Well or moderately differentiated adenocarcinoma; Poorly diff: Poorly differentiated adenocarcinoma or signet ring cell carcinoma; NS: Not significant.

Table 5 Relationship between ABC (D) stratification and endoscopic atrophic border in histological differentiation, well differentiated adenocarcinoma

	Endoscopic atrophic border
ABC (D) stratification	Non	Closed type	Open type	Total
A: H. pylori (-) PG (-)	1	2	5	8 (10.5%)
B: H. pylori (+) PG (-)	1	5	12	18 (23.7%)
C: H. pylori (+) PG (+)	0	7	40	47 (61.8%)
D: H. pylori (-) PG (+)	0	1	2	3 (3.9%)
Total	2 (2.6%)	15 (19.7%)	59 (77.6%)	76 (100%)

H. pylori: Helicobacter pylori; PG: Pepsinogen; Non: No atrophic change.

Table 6 Relationship between ABC (D) stratification and endoscopic atrophic border in histological differentiation, poorly differentiated adenocarcinoma

	Endoscopic atrophic border
ABC (D) stratification	Non	Closed type	Open type	Total
A: H. pylori (-) PG (-)	0	1	1	2 (10.6%)
B: H. pylori (+) PG (-)	0	2	7	9 (47.4%)
C: H. pylori (+) PG (+)	0	3	4	7 (36.8%)
D: H. pylori (-) PG (+)	0	0	1	1 (5.3%)
Total	0 (0%)	6 (31.6%)	13 (68.4%)	19 (100%)

H. pylori: Helicobacter pylori; PG: Pepsinogen; Non: No atrophic change.