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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 14, 2011; 17(42): 4689-4695
Published online Nov 14, 2011. doi: 10.3748/wjg.v17.i42.4689
Published online Nov 14, 2011. doi: 10.3748/wjg.v17.i42.4689
Table 1 Patient demographics, indications and colonoscopy findings
PEG + Asc | PEG + Sim | |
ITT patients | 72 | 72 |
Compliant patients (%) | 69 (96) | 61 (85) |
Cecal intubation (%) | 62 (86) | 68 (94) |
Median age (range) | 60.1 (20-84) | 57.6 (33-81) |
Male (%) | 40 (55) | 36 (50) |
Median timing of colonoscopy (min) | 22 | 21 |
Indications (%) | ||
Follow-up | 27 (37) | 18 (25) |
Surveillance | 8 (11) | 11 (15) |
CRC sreening | 15 (21) | 8 (11) |
Hematochezia | 13 (18) | 16 (22) |
Change in bowel habits | 3 (4) | 7 (10) |
Anemia | 2 (3) | 1 (2) |
Abdominal pain | 4 (6) | 11 (15) |
Findings (%) | ||
No abnormalities | 40 (55) | 24 (33) |
Diverticular disease | 14 (19) | 14 (19) |
Polyps/Malignancy | 13/2 (18/3) | 22/0 (31/0) |
IBD | 1 (2) | 3 (4) |
Other | 2 (3) | 9 (13) |
Table 2 Colonoscopy preparation schedules
PEG + Asc | 2 L from 6:00 to 8:00 PM (250 mL every 15 min) plus 500 mL of clear fluid for every L of solution, evening before colonoscopy |
Each liter of PEG + Asc (MoviPrep®) contains 100 g macrogol 3350, 7.5 g sodium sulfate, 2.7 g sodium chloride, 1 g potassium chloride, 4.7 g ascorbic acid, 5.9 g sodium ascorbate, and lemon flavoring | |
PEG + Sim | 2 L from 3:00 to 5:00 PM and 2 L from 6:00 to 8:00 PM (250 mL every 15 min), evening before colonoscopy |
Each liter of PEG + Sim (Selg®-Esse 1000) contains 58.3 g macrogol 4000, 0.08 g simethicone, 5.68 g sodium sulfate, 1.68 g sodium bicarbonate, 1.46 g sodium chloride and 0.74 g potassium chloride and mandarin aroma |
Table 3 Colonoscopy preparation assessments
Aronchick scale | |
1 Excellent | Small volume of clear liquid or greater than 95% of surface seen |
2 Good | Large volume of clear liquid covering 5% to 25% of surface but greater than 90% of surface seen |
3 Fair | Some semi-solid stool that could be suctioned or washed away but greater than 90% of surface seen |
4 Poor | Semi-solid stool that could not be suctioned or washed away and less than 90% of surface seen |
5 Inadequate | Repreparation needed |
Residual stool score (total in sum of three score) | |
Amount of residual stool | 0 = none |
1 = small | |
2 = moderate | |
3 = large | |
Consistency of residual stool | 0 = none |
1 = clear liquid | |
2 = colored liquid | |
3 = stool particles | |
4 = semi-solid stool | |
5 = solid stool | |
Percent bowel wall visualized | 0 ≥ 75% |
1 = 50%-75% | |
2 = 25%-49% | |
3 ≤ 25% |
Table 4 Patient drop-out: global bowel cleansing, side effects and findings
Drop out gut cleansing | PEG + Asc | PEG + Sim |
No. of patients | 3 | 11 |
Global bowel cleansing (%) | ||
Aronchick 1 | (1) | (2) |
Aronchick 2 | (1) | (5) |
Aronchick 3 | - | (2) |
Aronchick 4 | (1) | (2) |
Aronchick 5 | - | - |
Cecal Intubation (patients) | 2 | 11 |
Findings | ||
No abnormalities | 1 | 9 |
Polyps/malignancy | 0/1 | 2/0 |
Diverticular disease | 1 | - |
Other | - |
Table 5 Side effects in compliant patients (1multiple side effects possible)
PEG + Asc | PEG + Sim | |
No. of patients | 72 | 72 |
Side effects patients1 | 14 | 21 |
Nausea | 7 | 16 |
Vomiting | 4 | 5 |
Headache | 3 | 1 |
Insomnia | 1 | 1 |
Abdominal pain | 2 | 1 |
Table 6 Overall gut cleansing and cecal intubation performed
Overall gut cleansing | PEG + Asc | PEG + Sim |
No. of patients | 69 | 61 |
Aronchick 1 | 8/5 | 17/16 |
Aronchick 2 | 29/27 | 13/12 |
Aronchick 3 | 26/26 | 24/24 |
Aronchick 4 | 5/2 | 5/5 |
Aronchick 5 | 1/0 | 2/0 |
Table 7 Patient questionnaire findings by preparation group tolerability
Question | PEG + Asc | PEG + Sim |
Clear liquid at the time of the last evacuation | ||
Yes | 51 | 62 |
No | 21 | 10 |
Is this the first time you took a preparation for colonoscopy? | ||
Yes | 33 | 43 |
No | 39 | 29 |
Discomfort: | ||
None | 18 | 28 |
Slightest | 32 | 36 |
Moderate | 17 | 6 |
Severe | 5 | 2 |
How much would you be prepared to repeat this preparation for colonoscopy? | ||
A little | 18 | 15 |
Fairly | 32 | 42 |
Much | 15 | 11 |
I would never repeat | 7 | 4 |
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Citation: Pontone S, Angelini R, Standoli M, Patrizi G, Culasso F, Pontone P, Redler A. Low-volume plus ascorbic acid
vs high-volume plus simethicone bowel preparation before colonoscopy. World J Gastroenterol 2011; 17(42): 4689-4695 - URL: https://www.wjgnet.com/1007-9327/full/v17/i42/4689.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i42.4689