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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 7, 2011; 17(41): 4625-4631
Published online Nov 7, 2011. doi: 10.3748/wjg.v17.i41.4625
Published online Nov 7, 2011. doi: 10.3748/wjg.v17.i41.4625
Table 1 Clinicopathologic features n (%)
Characteristics | Number of patients (n = 81) |
Gender | |
Male | 58 (71.6) |
Female | 23 (28.4) |
Histology | |
Low-grade B-cell | 18 (22.2) |
High-grade B-cell | 42 (51.9) |
T cell | 21 (25.9) |
Stage | |
I~II | 66 (81.5) |
III~IV | 15 (18.5) |
Treatment | |
Surgery alone | 3 (3.7) |
Nonsurgical | 16 (19.8) |
Both | 61 (75.3) |
No | 1 (1.2) |
Treatment response | |
Complete remission | 56 (69.1) |
Partial remission | 7 (8.6) |
Stable disease | 3 (3.7) |
Progression | 15 (18.5) |
Table 2 Sites of origin n (%)
Sites of origin | Number of patients (n = 81) |
Duodenum | 2 (2.5) |
Jejunum | 4 (4.9) |
Ileum | 5 (6.2) |
Ileocaecal region | 31 (38.3) |
Colon | 20 (24.7) |
Rectum | 8 (9.9) |
Multiple sites | 11 (13.6) |
Table 3 Immunohistological phenotypes n (%)
Histologic type | Patients | Total(n = 81) | |
Male(n = 58) | Female(n = 23) | ||
B cell | 42 (72.4) | 18 (78.3) | 60 (74.1) |
MALT | 6 (10.3) | 9 (39.1) | 15 (18.5) |
Follicular lymphoma | 3 (5.2) | 0 (0.0) | 3 (3.7) |
Mantle cell lymphoma | 3 (5.2) | 0 (0.0) | 3 (3.7) |
DLBCL | 27 (46.6) | 8 (34.8) | 35 (43.2) |
Burkitt-like | 2 (3.4) | 1 (4.3) | 3 (3.7) |
Burkitt lymphoma | 1 (1.7) | 0 (0.0) | 1 (1.2) |
T cell | 16 (27.6) | 5 (21.7) | 21 (25.9) |
ETCL | 6 (10.3) | 1 (4.3) | 7 (8.6) |
Anaplastic | 3 (5.2) | 0 (0.0) | 3 (3.7) |
NK/T | 0 (0.0) | 1 (4.3) | 1 (1.2) |
PTCL, NOS | 4 (6.9) | 1 (4.3) | 5 (6.2) |
Others | 3 (5.2) | 2 (8.7) | 5 (6.2) |
Table 4 Prognostic factors on univariate analysis1
Characteristics | n = 81 | 5-year EFS | P value | 5-year OS | P value |
Age | |||||
59 or younger | 70 | 56.1 | 0.939 | 68.9 | 0.852 |
60 or older | 11 | 56.8 | 68.4 | ||
Gender | |||||
Male | 58 | 56.4 | 0.843 | 62.3 | 0.058 |
Female | 23 | 56.2 | 85.6 | ||
Sites of origin | |||||
Small intestine | 11 | 63.6 | 0.025 | 80.8 | 0.219 |
Ileocaecal region | 31 | 71.0 | 79.6 | ||
Colon | 20 | 54.5 | 65.2 | ||
Rectum | 8 | 37.5 | 50.0 | ||
Multiple sites | 11 | 27.3 | 46.8 | ||
Histology | |||||
Low-grade B-cell | 18 | 66.3 | 0.002 | 87.5 | < 0.001 |
High-grade B-cell | 42 | 71.3 | 79.2 | ||
T cell | 21 | 23.8 | 34.8 | ||
Stage | |||||
I~II | 66 | 58.8 | 0.387 | 69.0 | 0.727 |
III~IV | 15 | 45.7 | 71.4 | ||
Bulky disease | |||||
< 8 cm | 54 | 60.6 | 0.189 | 70.1 | 0.837 |
≥ 8 cm | 27 | 48.1 | 67.7 | ||
Perforation | |||||
Yes | 6 | 28.6 | 0.074 | 25.0 | 0.024 |
No | 75 | 58.9 | 72.5 | ||
B symptom | |||||
Yes | 34 | 55.1 | 0.768 | 59.5 | 0.172 |
No | 47 | 57.1 | 75.0 | ||
LDH | |||||
Elevated | 25 | 34.2 | 0.010 | 52.2 | 0.034 |
Normal | 56 | 65.9 | 76.9 | ||
Treatment | |||||
Surgery-based | 64 | 54.3 | 0.668 | 70.9 | 0.371 |
Nonsurgical | 16 | 61.9 | 60.9 | ||
Radical surgery | |||||
Yes | 54 | 57.7 | 0.218 | 70.3 | 0.599 |
No | 10 | 40.0 | 77.8 | ||
Period | |||||
A | 27 | 51.9 | 0.594 | 66.7 | 0.808 |
B | 54 | 58.8 | 71.3 |
Table 5 Prognostic factors assessed by multivariate analysis1
Variable | Overall survival | Event-free survival | ||
Exp(B) | P value | Exp (B) | P value | |
Pathology (B cell vs T cell) | 4.566 | 0.002 | 3.833 | 0.001 |
LDH (normal 240 U/L) | 1.002 | 0.013 | 1.003 | 0.002 |
Sites of origin | 1.370 | 0.052 | 1.442 | 0.010 |
Gender | 2.980 | 0.089 | NE | |
Perforation | 0.835 | 0.778 | 0.625 | 0.438 |
Table 6 Prognostic factors for the subgroups of B-cell lymphomas1
Variable | Overall survival | Event-free survival | ||
Exp(B) | P value | Exp (B) | P value | |
Pathology (subtypes of B cell lymphoma) | 1.426 | 0.174 | 1.141 | 0.500 |
LDH (normal 240 U/L) | 3.671 | 0.127 | 4.663 | 0.007 |
Gender | 16.328 | 0.037 | 0.804 | 0.716 |
Sites of origin | 1.604 | 0.050 | 1.306 | 0.151 |
- Citation: Wang GB, Xu GL, Luo GY, Shan HB, Li Y, Gao XY, Li JJ, Zhang R. Primary intestinal non-Hodgkin's lymphoma: A clinicopathologic analysis of 81 patients. World J Gastroenterol 2011; 17(41): 4625-4631
- URL: https://www.wjgnet.com/1007-9327/full/v17/i41/4625.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i41.4625