A meta-analysis of lamivudine for interruption of mother-to-child transmission of hepatitis B virus

doi:10.3748/wjg.v17.i38.4321

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2011; 17(38): 4321-4333
Published online Oct 14, 2011. doi: 10.3748/wjg.v17.i38.4321

Table 1 General information of included randomized controlled trials

First author, year^[Ref.]	Group (n)	Interventions on mothers	Maternal HBV DNA level¹		Newborns within 24 h			Infants within 6-12 mo			Adverse events
			Before intervention	Before delivery	HBsAg(+)	HBeAg(+)	HBV DNA (+)	HBsAg(+)	HBeAg(+)	HBV DNA (+)	Mothers	Infants
Zhang, 2010[21]	Arm 1:50	3TC 100 mg od from week 28	6.83 ± 0.90	3.65 ± 0.54	6/50	-	5/50	1/50	-	1/50	0	0
	Arm 2:50	No treatment	6.87 ± 1.67	6.88 ± 1.08	17/50	-	18/50	8/50	-	8/50	-	-
Han, 2010[22]	Arm 1:52	3TC 100 mg od from week 20	-	-	5/52	-	1/52	0/42	-	0/42	0	0
	Arm 2:61	200 IU HBIG every 2 wk from week 28	-	-	26/61	-	7/61	9/55	-	9/55	0	0
Han, 2009[23]	Arm 1:57	3TC 100 mg od from week 20	7.5 ± 0.50	-	6/57	-	1/57	0/46	-	0/46	0	0
	Arm 2:66	200 IU HBIG every 2 wk from week 28	7.5 ± 0.72	-	27/66	-	8/66	10/59	-	10/59	0	1/66
Su, 2009[24]	Arm 1:128	3TC 100 mg od from week 32, 200 IU HBIG at week 28, 32, 36	-	-	-	-	-	6/128	-	-	0	0
	Arm 2:120	200 IU HBIG at week 28, 32, 36	-	-	-	-	-	17/120	-		-	-
Xu, 2009[25]	Arm 1:63	3TC 100 mg od from week 32	9.35 ± 0.21	7.71 ± 1.49	17/5	-	7/56	10/56	-	11/56	7/89	10/56
	Arm 2:62	Placebo	9.43 ± 0.21	9.34 ± 0.22	14/59	-	24/59	23/59	-	27/59	6/61	12/59
Shi, 2009[26]	Arm 1:49	3TC 100 mg od from week 28	7.24 ± 1.90	4.49 ± 3.25	3/49	-	1/49	-	-	-	2/51	-
	Arm 2:116	100 IU HBIG at week 28, 32, 36	6.31 ± 2.13	5.86 ± 2.62	8/116	-	4/116	-	-	-	3/146	-
	Arm 3:43	Placebo	6.40 ± 2.12	6.19 ± 2.57	10/43	-	5/43	-	-	-	2/84	-
Yang, 2008[27]	Arm 1:45	3TC 100 mg od from week 24	6.99 ± 0.84	5.10 ± 0.80	-	-	-	1/45	-	-	-	0
	Arm 2:42	100 IU HBIG at week 28, 32, 36	6.87 ± 0.92	6.87 ± 0.92	-	-	-	6/42	-	-	-	0
Guo, 2008[28]	Arm 1:70	3TC 100 mg od from week 28	-	-	6/70	-	8/70	4/70	-	6/70	-	-
	Arm 1:40	No treatment	-	-	10/40	-	13/40	12/40	-	18/40	-	-
Xiang, 2007[29]	Arm 1:21	3TC 100 mg od from week 28	8.02 ± 1.15	4.58 ± 1.22	1/21	3/21	-	-	-	-	-	-
	Arm 2:25	200 IU HBIG every month from month 4	7.63 ± 1.23	5.12 ± 1.07	2/25	2/25	-	-	-	-	-	-
	Arm 3:18	No treatment	7.16 ± 0.79	6.88 ± 1.36	5/18	3/18	-	-	-	-	-	-
Feng, 2007[30]	Arm 1:48	3TC 100 mg od from week 28	8.34 ± 1.23	4.85 ± 1.27	8/48		9/48	7/48	-	7/48	0	0
	Arm 1:42	No treatment	8.26 ± 1.87	8.56 ± 1.08	17/42		19/42	16/42	-	16/42	0	0
Li, 2006[31]	Arm 1:36	3TC 100 mg od from week 24	6.89 ± 0.82	5.08 ± 0.76	-	-	-	1/36	-	-	0	0
	Arm 2:44	No treatment	> 5.00	> 5.00	-	-	-	7/44	-	-	0	0
Li, 2006[32]	Arm 1:40	3TC 100 mg od from week 28 and 200 IU HBIG at week 28, 32, 36	-	-	-	-	-	1/35	1/35	1/35	0	0
	Arm 2:37	200 IU HBIG at week 28, 32, 36	-	-	-	-	-	7/32	6/32	6/32	0	0
Han, 2005[33]	Arm 1:43	3TC 100 mg od from week 28	7.15 ± 0.91	5.43 ± 0.85	-	-	-	0/43	-	0/43	0	0
	Arm 1:35	No treatment	> 5.60	> 5.60	-	-	-	5/35	-	-	0	0
Shi, 2005[34]	Arm 1:21	3TC 100 mg od from week 28	8.72 ± 0.69	6.59 ± 1.06	1/21	3/21	2/21	-	-	-	1/21	0
	Arm 1:18	No treatment	8.93 ± 1.12	9.05 ± 0.26	1/18	2/18	8/18	-	-	-	0	0
Li, 2003[35]	Arm 1:56	200 IU HBIG every 4 wk from week 28	7.38 ± 1.17	5.28 ± 2.77	3/56	7/56	-	-	-	-	0	0
	Arm 2:43	3TC 100 mg od from week 28	7.49 ± 0.54	5.33 ± 1.34	1/43	7/43	-	-	-	-	0	0
	Arm 3:52	No treatment	7.05 ± 1.29	6.23 ± 3.66	8/52	11/52	-	-	-	-	0	0

3TC: Lamivudine; HBIG: Hepatitis B immunoglobulin; IU: International unit; mg: Milligram; od: Once daily; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; -: Data not available.

¹Log₁₀ HBV DNA (mean ± SD).

Table 2 Methodological quality of included randomized clinical trials

First author, year^[Ref.]	Generation of allocation sequence	Allocation concealment	Blinding	Methodologicalquality
Han, 2010[22]	Unclear	Unclear	Unclear	Low
Zhang, 2010[21]	Unclear	Unclear	Unclear	Low
Han, 2009[23]	Unclear	Unclear	Unclear	Low
Su, 2009[24]	Unclear	Unclear	Unclear	Low
Xu, 2009[25]	Unclear	Adequate	Adequate	High
Shi, 2009[26]	Adequate	Adequate	Adequate	High
Yang, 2008[27]	Adequate	Unclear	Unclear	Low
Guo, 2008[28]	Adequate	Unclear	Unclear	Low
Xiang, 2007[29]	Adequate	Unclear	Unclear	Low
Feng, 2007[30]	Not done	Not done	Not done	Low
Li, 2006[31]	Not done	Not done	Not done	Low
Li, 2006[32]	Not done	Not done	Not done	Low
Han, 2005[33]	Not done	Not done	Not done	Low
Shi, 2005[34]	Adequate	Unclear	Unclear	Low
Li, 2003[35]	Adequate	Unclear	Unclear	Low

Citation: Han L, Zhang HW, Xie JX, Zhang Q, Wang HY, Cao GW. A meta-analysis of lamivudine for interruption of mother-to-child transmission of hepatitis B virus. World J Gastroenterol 2011; 17(38): 4321-4333
URL: https://www.wjgnet.com/1007-9327/full/v17/i38/4321.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i38.4321