Comparison of Milan and UCSF criteria for liver transplantation to treat hepatocellular carcinoma

Table 1 Number of patients associated with each criteria depending on pre-orthotopic liver transplantation imaging and post-orthotopic liver transplantation pathology results n (%)

Diagnostic approaches	Milan +	Milan -/UCSF +	UCSF -
pre-OLT imaging	44 (78.0)	5 (8.9)	7 (12.5)
post-OLT pathology	34 (60.7)	7 (12.5)1	15 (26.8)2

¹6/7 patients were classified as “Milan +” based on pre-OLT imaging;

²4 patients each were classified as “UCSF +/Milan -” and “Milan +” based on pre-OLT imaging. UCSF: University of California San Francisco; OLT: Orthotopic liver transplantation.

Table 2 Patient characteristics according to Milan and University of California San Francisco criteria determined from post-orthotopic liver transplantation imaging and post-orthotopic liver transplantation pathological evaluations n (%)

Variables	Milan +	Milan -/UCSF +	UCSF -	P value
No. of patients	34	7	15
Gender (M/F)	29/5	7/0	14/1
Age (yr)	55.1 ± 6.6	51.0 ± 4.5	56.4 ± 5.5	0.222
CTP (A/B/C)	8/18/8	3/1/2003	10/4/2001
MELD	13.3 ± 4.9	12.7 ± 4.3	13.4 ± 4.3	0.803
AFP (ng/dL)	4.9	6.1	11.9	0.953
No. nodules	1.4 ± 0.6	2.4 ± 1.3	5.7 ± 4.4	0.000
Max diameter of largest nodule (mm)	22.5 ± 11.6	45.9 ± 11.5	47.9 ± 23.8	0.000
Grade
Well	17 (73.9)	2 (28.6)	4 (26.7)
Moderate	17 (53.1)	5 (71.4)	10 (66.7)
Poor			1 (6.6)
Microvascular invasion	6 (17.6)a	2 (28.6)	7 (46.7)a	0.034a

M: Male; F: Female; UCSF: University of California San Francisco; CTP: Child-Turcot-Pugh; MELD: Model of End-stage Liver Disease; AFP: α-fetoprotein.

^aP < 0.05.

Table 3 Follow-up data for patients who underwent orthotopic liver transplantation for hepatocellular carcinoma n (%)

Variables	Milan +	Milan -/UCSF +	UCSF -
No. of patients	34	7	15
Post-operative death	2 (5.9)	-	1 (4.5)
Death	5 (14.7)	2 (28.6)	11 (73.3)
HCC recurrence	2 (5.8)	1 (14.3)	6 (40.0)
Median follow-up	51.5 (1:124)	32 (1:66)	14 (3:66)

UCSF: University of California San Francisco; HCC: Hepatocellular carcinoma.

Table 4 Causes of mortality associated with cases in this study

Causes of death	n (%)
Sepsis (late postoperative period)	7 (36.8)
Lung metastasis	5 (26.3)
Sepsis (early postoperative period)	3 (15.8)
Recurrent fulminant hepatitis B	2 (10.5)
Duodenal ulcer perforation	1 (5.3)
Intracranial hemorrhage	1 (5.3)