Antioxidative potential of a combined therapy of anti TNFα and Zn acetate in experimental colitis

Table 1 Biochemical and morphological parameters of colitis severity among the study groups

	Macroscopic score	Colonic activity index	Myeloperoxidase activity (U/g)
Controls	0 (0-0)	0 (0-0)	1.9 (1.34-1.1)
Colitis	1 (1-1)b	4 (1-1)a	5.69 (0.04-0.21)b
Colitis + Zinc	2 (2-2)b	5 (0-0)a	7.8 (0-0.8)e
Colitis + anti-TNFα (25 μg)	0.5 (0-1)	4 (1-3)a	4.85 (1.81-3)d
Colitis + Zinc + anti-TNFα (25 μg)	0 (0-0)c	1 (2-0)ad	3.88 (2.9-2.87)
Colitis + anti-TNFα (6.25 μg)	1 (0.25-1)	5 (0-2)	5.44 (0.63-0)
Colitis + Zinc + anti-TNFα (6.25 μg)	0.5 (0-1)	3 (2-0)	4.42 (0.34-0.33)

^aP < 0.01 vs controls;

^bP < 0.03 vs controls;

^cP < 0.03 vs colitis;

^dP < 0.02 vs colitis+Zinc;

^eP < 0.02 vs controls. TNF: Tumour necrosis factor.