Role of high definition colonoscopy in colorectal adenomatous polyp detection

Table 1 Patient Characteristics n (%)

Parameters	HD group(n = 450)	SD2 group(n = 450)	P value
Patients
Mean age, years (SD1)	55 (± 12.5)	56 (± 11.4)	0.21
Men	213 (47.3)	208 (46)	0.86
Race
White	233 (51.8)	281 (62.4)	0.10
African American	49 (10.9)	53 (11.8)	0.75
Hispanic	139 (30.9)	95 (21.1)	0.01
Others	29 (6.4)	21 (4.7)	0.31
Indication
Screening	216 (48.0)	173 (38.4)	0.07
Non-screening	234 (52.0)	277 (61.6)	0.13
Cecal intubation	433 (96.2)	438 (97.3)	0.92
Poor prepare	14 (3.1)	17 (3.8)	0.72
Withdrawal all procedures, min (SD1)	11.3 (± 6.1)	10.8 (± 5.6)	0.20
Withdrawal non-polypectomy, min (SD1)	10.0 (± 5.9)	9.2 (± 4.2)	0.02

¹Standard deviation;

²Standard definition; HD: high definition; min: Minutes.

Table 2 Detection of all polyps, adenomas, and cancer n (%)

Parameters	HD group(n = 450)	SD2 group(n = 450)	P value
Total polyps detected	397	410	0.73
Non-adenomas	196 (51.3)	209 (52.0)	0.81
Non-advanced adenomas	150 (39.3)	150 (37.3)	0.84
Advanced adenomas	34 (8.9)	40 (10.0)	0.60
Cancer	2 (0.5)	3 (0.7)	1.00
Pathology not identified	15 (3.8)	8 (2.0)	0.14
< 6 mm	325 (81.9)	340 (82.9)	0.96
6-10 mm	50 (12.6)	44 (10.7)	0.45
> 10 mm	22 (5.5)	24 (5.9)	1.00
Size not specified	0	2	0.50
All patients
With non-adenomas	84 (18.7)	92 (20.4)	0.56
With non-advanced adenomas	84 (18.7)	83 (18.4)	1.00
With advanced adenomas	25 (5.6)	29 (6.4)	0.67
With cancer	2 (0.4)	3 (0.7)	1.00
Polyps per pt, mean (SD1)	0.88 (± 1.63)	0.91 (± 1.41)	0.77
Adenomas per pt, mean (SD1)	0.41 (± 1.04)	0.42 (± 0.94)	0.88
Advanced adenoma per pt, mean (SD1)	0.076 (± 0.35)	0.089 (± 0.38)	0.56
Adenocarcinoma per pt (mean)	0.004	0.006
Screening patients, n	216	173	0.07
With non-adenomas	49 (22.7)	36 (20.8)	0.81
With non-advanced adenomas	41 (19.0)	32 (18.5)	1.00
With advanced adenomas	13 (6.0)	14 (8.1)	0.55
With cancer	1 (0.5)	0 (0.0)	1.00
Non-screening patients, n	234	277	0.13
With non-adenomas	35 (15.0)	56 (20.2)	0.59
With non-advanced adenomas	43 (18.4)	51 (18.4)	0.21
With advanced adenomas	12 (5.1)	15 (5.4)	1.00
With cancer	1 (0.4)	3 (1.1)	0.63

¹Standard deviation;

²Standard definition; HD: high definition; Per pt: Per patient.

Table 3 Detection of all polyps, adenomas and cancer, with respect to gender n (%)

Parameters	HD group(n = 450)	SD group(n = 450)	P value
Male
Total polyps detected	264	245	0.74
Patients	213	208	0.86
With non-adenomas	42 (19.7)	46 (22.1)	0.48
With non-advanced adenomas	52 (24.4)	43 (20.7)	0.50
With advanced adenomas	17 (8.0)	21 (10.1)	0.50
With cancer	1 (0.5)	2 (1.0)	0.62
Female
Total polyps detected	133	165	0.21
Patients	237	242	0.87
With non-adenomas	42 (17.7)	46 (19.0)	0.82
With non-advanced adenomas	32 (13.5)	40 (16.5)	0.45
With advanced adenomas	8 (3.4)	8 (3.3)	1.00
With cancer	1 (0.4)	1 (0.4)	1.00

SD: Standard definition; HD: High definition.

Table 4 Comparison of standard vs high definition adenomatous polyp detection studies to date

Study	Date	Method	n	Colonoscope (resolution) (Angle) (NBI capable)		P value for adenomadetection rates
				Group 1	Group 2
East et al[13]	2008	Prospective nonrandomized	130	Olympus SD 140	Olympus HD 140	0.200
Pellise et al[12]	2008	Prospective randomized	620	Olympus SD 140	Olympus HD 170	0.850
Tribonias et al[14]	2010	Prospective randomized	390	Olympus SD 140	Olympus HD 170	0.160
Burke et al[16]	2010	Retrospective	852	Olympus SD 140	Olympus HD 170	0.360
Buchner et al[15]	2010	Retrospective	2430	Olympus SD 140	Olympus HD 170 NBI	0.012

NBI: Narrow-band imaging; SD: Standard definition; HD: High definition.