Effect of heme oxygenase-1 on renal function in rats with liver cirrhosis

Table 1 Effect of bile duct ligation and cobalt protoporphyrin or zinc protoporphyrin IX treatment on serum and urine levels of creatinine and sodium, and creatinine clearance rate (mean ± SD, n = 8-10 per group)

	Sham group	Cirrhosis group	CoPP group	ZnPP group
Serum Cre (μmol/L)	30.4 ± 1.81	36.3 ± 6.27a	33.5 ± 5.98	45.3 ± 8.92c
Urine Cre (μmol/L)	7.18 ± 1.15	8.08 ± 2.50	4.49 ± 1.51	6.31 ± 1.20
Serum sodium (mmol/L)	142.86 ± 3.44	138.75 ± 0.96a	142.64 ± 5.43c	136.57 ± 1.40c
Urine sodium (mmol/L)	91.50 ± 12.12	71.33 ± 10.07a	109.15 ± 64.93	66.25 ± 11.8
Ccr (mL/min)	0.23 ± 0.02	0.12 ± 0.05a	0.14 ± 0.04	0.07 ± 0.01c
AST (IU/L)	156.8 ± 18.28	237.2 ± 95.13a	467.14 ± 222.28c	209.11 ± 65.77

^aP < 0.05 vs sham group;

^cP < 0.05 vs cirrhotic group. CoPP: Cobalt protoporphyrin; ZnPP: Zinc protoporphyrin IX; Cre: Creatinine; Ccr: Creatinine clearance rate; AST: Aspartate aminotransferase.

Table 2 Effects of bile duct ligation and cobalt protoporphyrin or zinc protoporphyrin IX treatment on hemodynamic parameters, carboxyhemoglobin and 24-h urine volume (mean ± SD, n = 8-10 per group)

	Sham group	Cirrhosis group	CoPP group	ZnPP group
PVP (mmHg)	9.24 ± 0.76	15.56 ± 2.36b	17.28 ± 1.20	13.71 ± 1.39
MAP (cmH2O)	118.83 ± 8.09	59.23 ± 12.19b	52.75 ± 5.76	67.76 ± 7.66
COHb (%)	0.23 ± 0.05	0.50 ± 0.20a	0.83 ± 0.39c	0.23 ± 0.06c
RABF(mL/min•100 g)	3.89 ± 0.09	3.58 ± 0.04b	3.76 ± 0.06c	3.50 ± 0.08c
Urine (mL/24 h)	15.00 ± 2.23	10.93 ± 1.92a	13.5 ± 1.10c	8.50 ± 1.10c

^aP < 0.05,

^bP < 0.01 vs sham group;

^cP < 0.05 vs cirrhosis group. CoPP: Cobalt protoporphyrin; ZnPP: Zinc protoporphyrin IX; PVP: Portal vein pressure; MAP: Mean arterial pressure; COHb: Carboxyhemoglobin; RABF: Renal arterial blood flow.