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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 7, 2011; 17(25): 3035-3042
Published online Jul 7, 2011. doi: 10.3748/wjg.v17.i25.3035
Published online Jul 7, 2011. doi: 10.3748/wjg.v17.i25.3035
Table 1 Demography, clinical information and data on fractures in the peripheral skeleton of celiac disease patients and disease controls (Functional gastrointestinal disorders) at the time of the study
CD patients | Control population | P value | |
No. of patients (F/M) | 265 (223/42) | 530 (446/84) | |
Median age (yr) (range) | 42 (18-85) | 43 (16-87) | |
Age at diagnosis (yr) median (range) | 30 (1-80) | - | |
BMI (kg/m2, mean ± SE) | 22.5 ± 0.2 | 24.3 ± 0.2 | 0.001 |
Age at menarche (yr) median (range) | 13 (9-17) | 12 (9-20) | |
Age at menopause (yr) median (range) | 48 (30-54) | 49 (36-59) | |
Person-years before diagnosis | 7028 | 14 532 | |
Person-years after diagnosis | 2815 | 5628 | |
Total No. of fractures | 89 | 93 | 0.0001 |
Total No. of cases with at least one fracture | 61 | 82 | 0.02 |
No. of patients with at least one fracture before diagnosis | 40 | 45 | 0.006 |
No. of patients with at least one fracture after diagnosis | 21 | 37 | |
Age at first fracture before diagnosis (yr), median (range) | 10 (2-61) | 15 (1-74) | |
Age at first fracture after diagnosis (yr), median (range) | 21 (5-75) | 37 (6-71) | |
Type of trauma producing fracture (No. of cases) | |||
Mild | 27 | 24 | |
Moderate | 24 | 34 | |
Severe/sports | 10 | 24 |
Table 2 Clinical characteristics and fracture history of celiac disease patients according to gender
Female | Male | P value | |
No. of patients | 223 | 42 | |
Median age (yr), range | 42 (18-62) | 35 (18-66) | 0.04 |
Age at diagnosis (yr), median (range) | 31 (1-80) | 19 (1-52) | 0.003 |
BMI (kg/m2, mean ± SD) | 22.5 ± 0.5 | 23.7 ± 0.6 | 0.01 |
Person-years before diagnosis | 6380 | 647 | |
Person-years after diagnosis | 2371 | 444 | |
Total no. of fractures | 57 | 32 | 0.0001 |
Total no. of cases with at least one fracture | 42 | 19 | 0.0005 |
No. of patients with at least one fracture before diagnosis | 29 | 11 | 0.05 |
No. of patients with at least one fracture after diagnosis | 13 | 8 | 0.01 |
Age at first fracture before diagnosis (yr), median (range) | 14 (2-61) | 10 (6-32) | 0.04 |
Age at first fracture after diagnosis (yr), median (range) | 54 (5-75) | 13 (5-60) | |
Type of trauma producing first fracture (No. of cases) | |||
Mild | 20 | 7 | |
Moderate | 18 | 6 | |
Severe/sportive | 4 | 6 |
Table 3 Crude risk of fracture, adjusted risk of fractures and incidence rates (events/1000 subjects per year) in the peripheral skeleton in celiac disease patients compared to control population according to gender
CD patients | Controls | HR (95% CI) | P | |
Before diagnosis | ||||
Overall population | ||||
IR | 8.67 | 5.64 | 1.53 (1.05-2.14) | 0.01 |
Adjusted HR | 1.78 (1.23-2.56) | 0.002 | ||
Females | ||||
IR | 6.58 | 5.09 | 1.28 (0.87-1.88) | NS |
Adjusted HR | 1.52 (0.99-2.32) | 0.052 | ||
Males | ||||
IR | 29.35 | 10.20 | 2.67 (1.37-5.22) | 0.004 |
Adjusted HR | 2.63 (1.24-5.59) | 0.01 | ||
After diagnosis | ||||
Overall population | ||||
IR | 7.45 | 6.04 | 1.28 (0.74-2.21) | NS |
Adjusted HR | No significant change | |||
Females | ||||
IR | 5.48 | 5.30 | 1.08 (0.55-2.10) | NS |
Adjusted HR | No significant change | |||
Males | ||||
IR | 18.02 | 9.83 | 1.57 (0.57-4.26) | NS |
Adjusted HR | No significant change |
- Citation: Sánchez MIP, Mohaidle A, Baistrocchi A, Matoso D, Vázquez H, González A, Mazure R, Maffei E, Ferrari G, Smecuol E, Crivelli A, Paula JA, Gómez JC, Pedreira S, Mauriño E, Bai JC. Risk of fracture in celiac disease: Gender, dietary compliance, or both? World J Gastroenterol 2011; 17(25): 3035-3042
- URL: https://www.wjgnet.com/1007-9327/full/v17/i25/3035.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i25.3035