Keratinocyte growth factor gene therapy ameliorates ulcerative colitis in rats

doi:10.3748/wjg.v17.i21.2632

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Jun 7, 2011 (publication date) through Jul 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Jun 7, 2011; 17(21): 2632-2640
Published online Jun 7, 2011. doi: 10.3748/wjg.v17.i21.2632

Table 1 Changes of body weight and colonic weight/length ratio

Group	Body weight (g)	Colonic weight/length ratio (mg/cm)
SPK	272.78 ± 17.92^a^b	115.76 ± 7.47^a^b
SP	243.72 ± 14.02	150.32 ± 5.99
Control	240.68 ± 12.63	153.67 ± 5.50
Normal	286.64 ± 18.95^a^b	82.35 ± 4.63^a^b

Data are presented as mean ± SD, n = 6.

^aP < 0.05, vs control group,

^bP < 0.01, vs SP group. SP: Attenuated Salmonella typhimurium Ty21a strain; SPK: Attenuated Salmonella typhimurium Ty21a strain carrying human KGF gene.

Table 2 Changes in superoxide dismutase activity (U/mg) in colon tissues

Group	D3	D5	D7	D10
SPK	19.92 ± 4.22	26.18 ± 5.84^b^d	35.48 ± 3.35^b^d	46.10 ± 6.23^b^d
SP	18.29 ± 2.70	18.12 ± 3.30	22.57 ± 3.44	25.35 ± 4.76
Control	19.08 ± 3.57	18.79 ± 4.74	21.69 ± 3.94	27.82 ± 6.42
Normal	57.22 ± 4.03

Data are presented as mean ± SD, n = 6.

^bP < 0.01, vs SP groups,

^dP < 0.01, vs control group at the indicated time points. SP: Attenuated Salmonella typhimurium Ty21a strain; SPK: Attenuated Salmonella typhimurium Ty21a strain carrying human keratinocyte growth factor gene.

Table 3 Changes in malondialdehyde contents (nmol/mg) in colon tissues

Group	D3	D5	D7	D10
SPK	11.40 ± 0.92	10.33 ± 1.09	7.40 ± 0.88^b^d	4.36 ± 0.62^b^d
SP	10.99 ± 0.73	10.96 ± 1.02	9.81 ± 1.21	8.41 ± 0.92
Control	11.37 ± 1.23	11.03 ± 0.87	10.45 ± 1.40	8.71 ± 1.27
Normal	2.54 ± 0.67

Data are presented as mean ± SD, n = 6.

^bP < 0.01, vs SP and

^dP < 0.01, vs control group at the indicated time point. SP: Attenuated Salmonella typhimurium Ty21a strain; SPK: Attenuated Salmonella typhimurium Ty21a strain carrying human keratinocyte growth factor gene.

Citation: Liu CJ, Jin JD, Lv TD, Wu ZZ, Ha XQ. Keratinocyte growth factor gene therapy ameliorates ulcerative colitis in rats. World J Gastroenterol 2011; 17(21): 2632-2640
URL: https://www.wjgnet.com/1007-9327/full/v17/i21/2632.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i21.2632