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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 14, 2011; 17(2): 197-206
Published online Jan 14, 2011. doi: 10.3748/wjg.v17.i2.197
Published online Jan 14, 2011. doi: 10.3748/wjg.v17.i2.197
Table 1 Description of study participants n (%)
CD (n = 327) | UC (n = 495) | Controls (n = 779) | |
Sex | |||
Male | 129 (39) | 239 (48) | 400 (51) |
Female | 198 (61) | 256 (51) | 379 (49) |
Age (yr) | |||
Median (5%-95%) | 43 (23-76) | 49 (24-76) | 43 (23-60) |
Age at diagnosis (yr) | |||
Median (5%-95%) | 30 (15-64) | 35 (17-68) | |
Smoking habits | |||
Smokers | 167 (51) | 86 (17) | 205 (26) |
Never smokers | 115 (35) | 226 (46) | 391 (50) |
Former smokers | 45 (14) | 183 (37) | 183 (23) |
Location of UC | |||
Proctitis (E1) | 207 (42) | ||
Left side (E2) | 183 (37) | ||
Extensive (E3) | 93 (19) | ||
Data not available | 12 (2) | ||
Location of CD | |||
Colonic (L2) | 151 (46) | ||
Ileal (L1) | 74 (23) | ||
Ileocolonic (L3) | 89 (27) | ||
Data not available | 13 (4) | ||
Medication | |||
Advanced1 | 140 (43) | 103 (21) | |
No advanced medication2 | 182 (56) | 389 (79) | |
Data not available | 5 (2) | 3 (1) | |
Operation | |||
Yes | 149 (46) | 14 (3) | |
No | 171 (52) | 472 (95) | |
Data not available | 7 (2) | 9 (2) |
Table 2 Allele frequencies for the gene polymorphisms in Crohn’s disease and ulcerative colitis patients n (%)
CD | UC | Controls | |
NF-κB -94ins/del | |||
I | 379 (58) | 583 (59) | 919 (59) |
D | 275 (42) | 407 (41) | 639 (41) |
PPARγ Pro12Ala | |||
C | 564 (86) | 844 (85) | 1315 (84) |
G | 90 (14) | 146 (15) | 243 (16) |
PPARγ C1431T | |||
C | 560 (86) | 832 (84) | 1327 (85) |
T | 94 (14) | 158 (16) | 231 (15) |
PXR rs1523127 | |||
A | 395 (60) | 570 (58) | 926 (59) |
C | 259 (40) | 420 (42) | 632 (41) |
PXR rs2276707 | |||
C | 540 (83) | 825 (83) | 1275 (82) |
T | 114 (17) | 165 (17) | 283 (18) |
PXR rs6785049 | |||
A | 426 (65) | 615 (62) | 1011 (65) |
G | 228 (35) | 375 (38) | 547 (35) |
LXR rs1405655 | |||
T | 435 (67) | 675 (68) | 1079 (69) |
C | 219 (33) | 315 (32) | 479 (31) |
LXR rs2695121 | |||
T | 292 (45) | 430 (43) | 727 (47) |
C | 362 (55) | 560 (57) | 831 (53) |
Table 3 Odds ratio for the studied gene polymorphisms in Crohn’s disease and ulcerative colitis patients
CD | UC | Control | ORCD | 95% CI1 | P value | ORUC | 95% CI1 | P value | |
NF-κB -94ins/del | |||||||||
II | 107 | 175 | 267 | 1.00 | - | 1.00 | - | ||
ID | 165 | 233 | 385 | 1.08 | 0.80-1.46 | 0.62 | 0.94 | 0.72-1.21 | 0.62 |
DD | 55 | 87 | 127 | 1.21 | 0.81-1.81 | 0.36 | 1.04 | 0.73-1.47 | 0.83 |
ID and DD | 220 | 320 | 512 | 1.11 | 0.83-1.48 | 0.48 | 0.96 | 0.75-1.23 | 0.76 |
PPARγ Pro12Ala | |||||||||
CC | 240 | 364 | 549 | 1.00 | - | 1.00 | - | ||
CG | 84 | 116 | 217 | 0.88 | 0.65-1.20 | 0.43 | 0.83 | 0.63-1.09 | 0.17 |
GG | 3 | 15 | 13 | 0.48 | 0.13-1.77 | 0.27 | 2.30 | 1.04-5.08 | 0.04 |
CG and GG | 87 | 131 | 230 | 0.86 | 0.64-1.16 | 0.33 | 0.90 | 0.69-1.17 | 0.42 |
PPARγ C1431T | |||||||||
CC | 241 | 352 | 561 | 1.00 | - | 1.00 | - | ||
CT | 78 | 128 | 205 | 0.81 | 0.59-1.12 | 0.20 | 1.00 | 0.76-1.31 | 0.99 |
TT | 8 | 15 | 13 | 1.36 | 0.54-3.42 | 0.52 | 1.95 | 0.90-4.27 | 0.09 |
CT and TT | 86 | 143 | 218 | 0.85 | 0.62-1.15 | 0.29 | 1.05 | 0.81-1.37 | 0.69 |
PXR rs1523127 | |||||||||
AA | 114 | 160 | 280 | 1.00 | - | 1.00 | - | ||
AC | 167 | 250 | 366 | 1.06 | 0.79-1.43 | 0.71 | 1.15 | 0.89-1.50 | 0.29 |
CC | 46 | 85 | 133 | 0.89 | 0.59-1.35 | 0.59 | 1.11 | 0.78-1.56 | 0.57 |
AC and CC | 213 | 335 | 499 | 1.02 | 0.77-1.35 | 0.91 | 1.14 | 0.89-1.46 | 0.30 |
PXR rs2276707 | |||||||||
CC | 223 | 339 | 517 | 1.00 | - | 1.00 | - | ||
CT | 94 | 147 | 241 | 0.92 | 0.68-1.24 | 0.57 | 0.97 | 0.75-1.26 | 0.84 |
TT | 10 | 9 | 21 | 1.25 | 0.56-2.76 | 0.58 | 0.67 | 0.30-1.51 | 0.33 |
CT and TT | 104 | 156 | 262 | 0.94 | 0.71-1.26 | 0.69 | 0.95 | 0.74-1.22 | 0.68 |
PXR rs6785049 | |||||||||
AA | 137 | 184 | 334 | 1.00 | - | 1.00 | - | ||
AG | 152 | 247 | 343 | 1.12 | 0.84-1.49 | 0.46 | 1.35 | 1.05-1.74 | 0.02 |
GG | 38 | 64 | 102 | 0.91 | 0.58-1.40 | 0.66 | 1.18 | 0.81-1.71 | 0.39 |
AG and GG | 190 | 311 | 445 | 1.07 | 0.81-1.40 | 0.65 | 1.31 | 1.03-1.66 | 0.03 |
LXR rs1405655 | |||||||||
TT | 143 | 229 | 383 | 1.00 | - | 1.00 | - | ||
CT | 149 | 217 | 313 | 1.26 | 0.95-1.68 | 0.11 | 1.22 | 0.95-1.57 | 0.11 |
CC | 35 | 49 | 83 | 1.12 | 0.71-1.78 | 0.62 | 1.01 | 0.67-1.51 | 0.97 |
CT and CC | 184 | 266 | 396 | 1.23 | 0.94-1.62 | 0.13 | 1.18 | 0.93-1.49 | 0.17 |
LXR rs2695121 | |||||||||
TT | 62 | 88 | 170 | 1.00 | - | 1.00 | - | ||
CT | 168 | 254 | 387 | 1.28 | 0.90-1.83 | 0.17 | 1.30 | 0.95-1.77 | 0.10 |
CC | 97 | 153 | 222 | 1.21 | 0.82-1.79 | 0.34 | 1.41 | 1.00-1.98 | 0.05 |
CT and CC | 265 | 407 | 609 | 1.26 | 0.89-1.76 | 0.19 | 1.34 | 0.99-1.79 | 0.06 |
Table 4 Odds ratio for the gene polymorphisms among Crohn’s disease and ulcerative colitis never smokers
NS-CD | NS-UC | NS-control | ORNS-CD | 95% CI1 | P value | ORNS-UC | 95% CI1 | P value | ORNS-IBD | 95% CI1 | P value | |
NF-κB -94ins/del | ||||||||||||
II | 40 | 79 | 136 | 1.00 | - | 1.00 | - | 1.00 | - | |||
ID | 56 | 109 | 194 | 0.99 | 0.62-1.57 | 0.97 | 0.98 | 0.68-1.42 | 0.93 | 0.98 | 0.71-1.36 | 0.92 |
DD | 19 | 38 | 61 | 1.07 | 0.57-2.00 | 0.83 | 1.09 | 0.67-1.79 | 0.72 | 1.09 | 0.70-1.68 | 0.71 |
ID and DD | 75 | 147 | 255 | 1.01 | 0.65-1.56 | 0.97 | 1.01 | 0.72-1.43 | 0.95 | 1.01 | 0.74-1.37 | 0.96 |
PPARγ Pro12Ala | ||||||||||||
CC | 83 | 167 | 270 | 1.00 | - | 1.00 | - | 1.00 | - | |||
CG | 31 | 50 | 117 | 0.86 | 0.54-1.38 | 0.54 | 0.71 | 0.48-1.04 | 0.08 | 0.75 | 0.54-1.05 | 0.09 |
GG | 1 | 9 | 4 | 0.80 | 0.09-7.29 | 0.84 | 3.99 | 1.20-13.32 | 0.02 | 2.77 | 0.85-9.00 | 0.09 |
CG and GG | 32 | 59 | 121 | 0.86 | 0.54-1.37 | 0.53 | 0.81 | 0.56-1.17 | 0.26 | 0.82 | 0.59-1.13 | 0.21 |
PPARγ C1431T | ||||||||||||
CC | 85 | 163 | 285 | 1.00 | - | 1.00 | - | 1.00 | - | |||
CT | 26 | 56 | 100 | 0.88 | 0.53-1.44 | 0.60 | 0.98 | 0.67-1.44 | 0.93 | 0.93 | 0.67-1.31 | 0.70 |
TT | 4 | 7 | 6 | 2.16 | 0.59-7.90 | 0.24 | 2.05 | 0.67-6.26 | 0.21 | 2.06 | 0.75-5.67 | 0.16 |
CT and TT | 30 | 63 | 106 | 0.95 | 0.59-1.53 | 0.83 | 1.04 | 0.72-1.51 | 0.82 | 1.00 | 0.72-1.39 | 0.99 |
PXR rs1523127 | ||||||||||||
AA | 43 | 74 | 149 | 1.00 | - | 1.00 | - | 1.00 | - | |||
AC | 51 | 103 | 176 | 1.01 | 0.64-1.60 | 0.97 | 1.15 | 0.79-1.67 | 0.46 | 1.11 | 0.80-1.53 | 0.54 |
CC | 21 | 49 | 66 | 1.10 | 0.60-1.99 | 0.77 | 1.52 | 0.95-2.41 | 0.08 | 1.36 | 0.90-2.05 | 0.15 |
AC and CC | 72 | 152 | 242 | 1.03 | 0.67-1.59 | 0.89 | 1.25 | 0.88-1.77 | 0.21 | 1.17 | 0.87-1.59 | 0.30 |
PXR rs2276707 | ||||||||||||
CC | 73 | 150 | 260 | 1.00 | - | 1.00 | - | 1.00 | - | |||
CT | 36 | 70 | 119 | 1.08 | 0.69-1.70 | 0.74 | 1.03 | 0.72-1.47 | 0.89 | 1.04 | 0.76-1.43 | 0.81 |
TT | 6 | 6 | 12 | 1.76 | 0.64-4.86 | 0.27 | 0.86 | 0.31-2.34 | 0.76 | 1.16 | 0.51-2.63 | 0.73 |
CT and TT | 42 | 76 | 131 | 1.14 | 0.74-1.76 | 0.55 | 1.01 | 0.71-1.43 | 0.96 | 1.05 | 0.77-1.43 | 0.75 |
PXR rs6785049 | ||||||||||||
AA | 42 | 77 | 168 | 1.00 | - | 1.00 | - | 1.00 | - | |||
AG | 52 | 119 | 176 | 1.19 | 0.75-1.88 | 0.47 | 1.49 | 1.04-2.13 | 0.03 | 1.38 | 1.01-1.89 | 0.05 |
GG | 21 | 30 | 47 | 1.79 | 0.97-3.31 | 0.06 | 1.40 | 0.82-2.39 | 0.22 | 1.53 | 0.97-2.43 | 0.07 |
AG and GG | 73 | 149 | 223 | 1.31 | 0.85-2.02 | 0.21 | 1.47 | 1.04-2.07 | 0.03 | 1.41 | 1.05-1.91 | 0.02 |
LXR rs1405655 | ||||||||||||
TT | 43 | 95 | 203 | 1.00 | - | 1.00 | - | 1.00 | - | |||
CT | 55 | 106 | 154 | 1.69 | 1.07-2.65 | 0.02 | 1.54 | 1.08-2.18 | 0.02 | 1.58 | 1.16-2.16 | 0.004 |
CC | 17 | 25 | 34 | 2.32 | 1.19-4.55 | 0.01 | 1.66 | 0.93-2.95 | 0.09 | 1.85 | 1.12-3.07 | 0.02 |
CT and CC | 72 | 131 | 188 | 1.80 | 1.18-2.77 | 0.01 | 1.56 | 1.11-2.17 | 0.01 | 1.63 | 1.21-2.20 | 0.001 |
LXR rs2695121 | ||||||||||||
TT | 15 | 30 | 90 | 1.00 | - | 1.00 | - | 1.00 | - | |||
CT | 59 | 126 | 197 | 1.82 | 0.98-3.39 | 0.06 | 1.98 | 1.23-3.17 | 0.005 | 1.93 | 1.28-2.92 | 0.002 |
CC | 41 | 70 | 104 | 2.37 | 1.23-4.57 | 0.01 | 2.09 | 1.25-3.49 | 0.005 | 2.18 | 1.39-3.41 | 0.0007 |
CT and CC | 100 | 196 | 301 | 2.01 | 1.11-3.64 | 0.02 | 2.01 | 1.28-3.17 | 0.002 | 2.02 | 1.36-2.99 | 0.0005 |
Table 5 Minor allele frequencies of pregnane X receptor polymorphisms in studied populations
Table 6 Published associations between pregnane X receptor polymorphisms and inflammatory bowel disease risk
Cases | Controls | C-25385T (rs3814055) | A-24381C (rs1523127) | C8055T (rs2276707) | A7635G (rs6785049) | ||
Danish1 | 822 | 779 | Neg | Neg | Variant | Present study | |
Irish2 | 422 | 336 | Wild-type | Wild-type | Variant | Wild-type | Dring et al[47] |
Scottish2 | 715 | 334 | Neg | Ho et al[49] | |||
Spanish2 | 696 | 550 | Variant | Wild-type | Martínez et al[50] | ||
Canadian3 | 270 | 336 | Neg | Neg | Amre et al[48] |
- Citation: Andersen V, Christensen J, Ernst A, Jacobsen BA, Tjønneland A, Krarup HB, Vogel U. Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease. World J Gastroenterol 2011; 17(2): 197-206
- URL: https://www.wjgnet.com/1007-9327/full/v17/i2/197.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i2.197