Mechanism and dose-effect of Ginkgolide B on severe acute pancreatitis of rats

doi:10.3748/wjg.v17.i17.2241

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May 7, 2011 (publication date) through May 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 7, 2011; 17(17): 2241-2247
Published online May 7, 2011. doi: 10.3748/wjg.v17.i17.2241

Table 1 Serum levels of amylase and PLA₂, quantity of ascites and pathological scores (n = 10) (mean ± SD)

Group	Amylase (U/L)	PLA₂ (μmol/min per mililiter)	Ascites (mL)	Pathological scores
SO	1923 ± 527^a^c	0.0434 ± 0.019^a^c	0.0^a^c	0^a^c
SAP	6448 ± 240^c	0.2990 ± 0.0225^c	5.4 ± 1.3^c	9.15 ± 0.55^c
DMSO	6070 ± 464^c	0.2728 ± 0.4461^c	5.0 ± 2.0^c	9.10 ± 0.65^c
BN1	4744 ± 1031^a^c	0.2320 ± 0.0890^a^c	2.4 ± 0.9^a	6.65 ± 0.42^a
BN2	3452 ± 548^a	0.1049 ± 0.0528^a	1.6 ± 0.5^a	5.55 ± 0.36^a
BN3	4777 ± 168^a^c	0.1069 ± 0.0440^a	2.6 ± 0.9^a	5.90 ± 0.19^a
SS	4646 ± 675^a^c	0.1632 ± 0.0523^a^c	2.4 ± 0.5^a	5.70 ± 0.30^a

PLA₂: Phospholipase A2; SO: Sham-operation; SAP: Severe acute pancreatitis; BN1: 2.5 mg/kg BN52021; BN2: 5.0 mg/kg BN52021; BN3: 10 mg/kg BN52021; SS: 20 μg/kg Sandostatin.

^aP < 0.05 vs SAP group;

^cP < 0.05 vs BN2 group.

Table 2 Expression of platelet activating factor receptor in pancreatic tissues (n = 10) (mean ± SD)

Group	Ratio of PAFR/β-actin mRNA	IOD of PAFR
SO	0.46 ± 0.10^a	5394.6 ± 1739.4^a
SAP	0.38 ± 0.08^c	1881.2 ± 376.7^c
DMSO	0.39 ± 0.09^c	2105.4 ± 345.2^c
BN1	0.54 ± 0.14^a	19966.7 ± 6488.7^a
BN2	0.60 ± 0.09^a	20935.6 ± 6551.9^a
BN3	0.60 ± 0.09^a	2169.7 ± 6872.5^a
SS	0.59 ± 0.08^a	20897.5 ± 666.2^a

PAFR: Platelet activating factor receptor; IOD: Integrated optical density; SO: Sham-operation; SAP: Severe acute pancreatitis; BN1: 2.5 mg/kg BN52021; BN2: 5.0 mg/kg BN52021; BN3: 10 mg/kg BN52021; SS: 20 μg/kg Sandostatin.

^aP < 0.05 vs SAP group,

^cP < 0.05 vs BN2 group.

Citation: Ji RL, Xia SH, Di Y, Xu W. Mechanism and dose-effect of Ginkgolide B on severe acute pancreatitis of rats. World J Gastroenterol 2011; 17(17): 2241-2247
URL: https://www.wjgnet.com/1007-9327/full/v17/i17/2241.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i17.2241