Pavlidou A, Dalamaga M, Kroupis C, Konstantoudakis G, Belimezi M, Athanasas G, Dimas K. Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR. World J Gastroenterol 2011; 17(12): 1614-1621 [PMID: 21472129 DOI: 10.3748/wjg.v17.i12.1614]
Corresponding Author of This Article
Anastasia Pavlidou, MSc, Department of Clinical Biochemistry, Attikon University Hospital, Athens 12462, Vassileos Georgiou 35, Malessina 35001, Fthiotida, Greece. anastasiada@hotmail.com
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Table 6 Association of mRNA expression survivin splice variants with clinicopathological characteristics in 52 patients suffering from colorectal cancer (mean ± SD)
Clinical characteristics
n
Wild-sur (copies/μL)
P value wild-sur
Sur-2b (copies/μL)
P value sur-2b
Sur-ΔEx3 (copies/μL)
P value sur-ΔEx3
Sur-2b/wildsur (copies/μL)
P value sur-2b/wildsur
Sur-ΔEx3/wildsur (copies/μL)
P value sur-ΔEx3/wildsur
Gender
0.978
0.685
0.631
0.570
0.387
Male
20
1216.1 ± 3438.6
98.0 ± 299.7
834.8 ± 3085.6
0.08 ± 0.09
0.47 ± 0.39
Female
32
589.5 ± 1259.1
31.1 ± 33.2
85.3 ± 117.1
0.17 ± 0.24
0.36 ± 0,41
Tumor size
0.088
0.438
0.869
0.544
0.097
≤ 5 cm
32
308.4 ± 491.3
28.6 ± 34.6
96.2 ± 116.1
0.17 ± 0.24
0.48 ± 0.41
> 5 cm
17
1949.4 ± 3956.2
119.3 ± 330.9
1055.8 ± 3531.9
0.09 ± 0.09
0.23 ± 0.24
Dukes stage
0.469
0.737
0.544
0.351
0.097
A
8
212.4 ± 403.4
27.7 ± 27.7
51.7 ± 66.1
0.37 ± 0.40
0.44 ± 0.35
B
11
476.9 ± 743.4
30.8 ± 45.8
137.7 ± 185.7
0.08 ± 0.12
0.37 ± 0.37
C
22
1556.8 ± 3533.1
95.4 ± 292.5
782.6 ± 3019.7
0.09 ± 0.10
0.30 ± 0.39
D
8
226.7 ± 146.7
35.6 ± 32.9
120.7 ± 66.5
0.15 ± 0.15
0.63 ± 0.35
T
0.006
0.125
0.041
0.103
0.492
0-2
8
212.4 ± 403.4
27.7 ± 27.7
51.7 ± 66.1
0.37 ± 0.40
0.44 ± 0.35
3
29
340.0 ± 521.1
26.5 ± 35.4
92.9 ± 127.2
0.10 ± 0.13
0.39 ± 0.37
4
12
2620.8 ± 4579.4
162.9 ± 389.8
1413.2 ± 4056.1
0.10 ± 0.08
0.40 ± 0.44
Histologic type
0.584
0.030
0.731
0.061
0.892
Polypoid (ecblastetic)
28
520.1 ± 1006.4
45.7 ± 56.2
141.2 ± 313.7
0.19 ± 0.25
0.31 ± 0.25
Ulcerous
21
1354.5 ± 3550.4
79.3 ± 298.5
769.5 ± 3083.3
0.06 ± 0.06
0.54 ± 0.51
Citation: Pavlidou A, Dalamaga M, Kroupis C, Konstantoudakis G, Belimezi M, Athanasas G, Dimas K. Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR. World J Gastroenterol 2011; 17(12): 1614-1621