Etiological and clinicopathologic characteristics of intrahepatic cholangiocarcinoma in young patients

Table 1 Risk factors for intrahepatic cholangiocarcinoma n (%)

Risk factors	Group I (n = 40)	Group II (n = 277)	P value
HBV infection	34 (85.0)	120 (43.3)	0.000
HCV infection	0 (0.0)	1 (0.4)	0.703
Liver cirrhosis			0.038
Related to HBV	16 (40.0)	68 (24.5)	0.347
Related to alcohol	0 (0.0)	6 (2.2)	0.392
Other causes	0 (0.0)	5 (1.8)
Total	16 (40.0)	79 (28.52)
Hepatolithiasis	0 (0.0)	25 (9.0)	0.000
Liver schistosomiasis	0 (0.0)	16 (5.8)	0.119

HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 2 Comparison of clinical features of ICC between the two groups n (%)

	Group I (n = 40)	Group II (n = 277)	P value
Gender (M/F)	30/10	193/84	0.491
ALT (> 42 U/L)	15 (60.00)	89 (32.13)	0.499
AST (> 37 U/L)	12 (30.00)	103 (37.18)	0.377
TBIL (> 20 μmol/L)	7 (17.50)	62 (22.38)	0.484
Albumin (g/L)	43.82 ± 4.27	42.07 ± 5.12	0.236
GGT (> 64 U/L)	19 (47.50)	176 (63.54)	0.051
ALP (> 119 U/L)	15 (11.19)	134 (48.38)	0.198
AFP (> 400 μg/L)	7 (17.50)	17 (6.14)	0.011
CA19-9 (> 37 U/mL)	14 (35.00)	153 (55.23)	0.017

M: Male; F: Female; TBIL: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; AFP: α-fetoprotein; ALP: Alkaline phosphatase; r-GT: r-glutamyl-transferase; CA 19-9: Carbohydrate antigen 19-9. Group I: ICC patients aged ≤ 40 years; Group II: ICC patients aged > 40 years.

Table 3 Comparison of pathological features of ICC between the two groups n (%)

	Group I (n = 40)	Group II (n = 277)	P value
Tumor location			0.827
Right lobe	25 (6.25)	160 (57.76)
Left lobe	14 (35.00)	111 (40.07)
Both lobes	1 (2.50)	6 (15.00)
Tumor size (cm)	6.80 ± 3.92	6.67 ± 3.38	0.892
Tumor number			0.474
1	36 (90.00)	258 (93.14)
≥ 2	4 (10.00)	19 (6.86)
Histological inflammation	15 (37.50)	47 (16.97)	0.002
Capsule	5 (12.50)	35 (12.64)	0.981
Tumor differentiation			0.506
Well	0 (0.00)	9 (3.25)
Moderate	29 (72.50)	191 (68.95)
Poor	11 (27.50)	71 (25.63)
Microvascular invasion	10 (25.00)	41 (14.80)	0.101
Perineural infiltration	0 (0.00)	4 (1.44)	0.444
Portal vein invasion	3 (7.50)	30 (10.83)	0.519
Lymphatic metastasis	8 (20.00)	46 (16.61)	0.594
Microscopic satellite lesion	7 (17.50)	69 (24.91)	0.305
Immunohistochemical examinations
Ck18 positive	38 (95.00)	269 (97.11)	0.475
Ck19 positive	40 (100.00)	267 (93.39)	0.222

Ck: Cytokeratin.