Short-segment Barrett’s esophagus and cardia intestinal metaplasia: A comparative analysis

Table 1 Incidence of dysplasia in short-segment Barrett’s esophagus and cardia intestinal metaplasia patients

Patients	n	Dysplasia	%
CIM	41	1	2.4
SSBE	32	4	12.5b

^bP < 0.01 vs cardia intestinal metaplasia (CIM). Biopsy specimens taken from 41 CIM patients and 32 short-segment Barrett’s esophagus (SSBE) patients were stained with hematoxylin and eosin. The incidence of dysplasia was calculated. The incidence of dysplasia was significantly higher in SSBE patients than in CIM patients (12.5% vs 2.4%, P < 0.01).

Table 2 Incidence of incomplete intestinal metaplasia in short-segment Barrett’s esophagus and cardia intestinal metaplasia patients

Patients	n	Incomplete IM	Complete IM	%
CIM	41	8	33	19.5
SSBE	32	21	11	65.6b
Total	73	29	44	39.7

^bP < 0.01 vs cardia intestinal metaplasia (CIM). Eight biopsy specimens taken from the lower esophagus and cardia were stained with hematoxylin/eosin, Alcian blue/periodic acid-Schiff (pH 2.5), AB/high iron diamine or Gimenez dyes. The prevalence of incomplete intestinal metaplasia (IM) was significantly higher in short-segment Barrett’s esophagus (SSBE) patients than in CIM patients (65.6% vs 19.5%, P < 0.01).

Table 3 Incidence of reflux symptomatic, endoscopic, or histological markers of gastroesophageal reflux disease in short-segment Barrett’s esophagus and cardia intestinal metaplasia patients n (%)

Patients	n	Reflux symptoms	Endoscopic esophagitis	Histological features of reflux esophagitis
CIM	41	12 (29.3)	5 (12.2)	12 (29.3)
SSBE	32	26 (81.2)b	30 (93.8)b	31 (96.9)b

^bP < 0.01 vs cardia intestinal metaplasia (CIM). All patients were questioned about symptoms of gastroesophageal reflux disease (GERD). Endoscopic signs of esophagitis were recorded and graded. All biopsy specimens were stained with hematoxylin and eosin. Alcian blue/periodic acid-Schiff (pH 2.5) was used to show the presence of acid mucins. The incidence of reflux symptomatic, endoscopic, or histological markers of GERD was higher in short-segment Barrett’s esophagus (SSBE) patients than in CIM patients (P < 0.01).

Table 4 Relation between Helicobacter pylori infection and antral intestinal metaplasia in short-segment Barrett’s esophagus and cardia intestinal metaplasia patients n (%)

Patients	n	Cardia H. pylori infection	Antral IM	Antral H. pylori infection
CIM	41	18 (43.9)	21 (51.2)	20 (48.8)
SSBE	32	5 (15.6)a	4 (12.5)b	7 (21.9)a

^aP < 0.05,

^bP < 0.01 vs cardia intestinal metaplasia (CIM). Eight biopsy specimens taken from the lower esophagus, cardia, and gastric antrum were stained with Alcian blue/periodic acid-Schiff (pH 2.5) and Gimenez dyes, respectively. The incidence of Helicobacter pylori (H. pylori) infection and antral intestinal metaplasia (IM) was lower in short-segment Barrett’s esophagus (SSBE) patients than in CIM patients (^aP < 0.05, ^bP < 0.01).