Copyright
©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 28, 2010; 16(48): 6123-6127
Published online Dec 28, 2010. doi: 10.3748/wjg.v16.i48.6123
Published online Dec 28, 2010. doi: 10.3748/wjg.v16.i48.6123
Table 1 Characteristics of the patients (mean ± SD)
Controls | Patients | |
Age | 6 yr 9 mo | 7 yr 8 mo |
Sex | 15 males | 20 males |
INR (%) | 1.05 ± 0.09 | 1.35 ± 0.21 |
ALT (UI/L) | 31.15 ± 13.83 | 25.45 ± 14.71 |
AST (UI/L) | 37.23 ± 11.86 | 31.42 ± 11.90 |
GGT (UI/L) | 16.46 ± 16.89 | 17.68 ± 18.40 |
Albumin (g/dL) | 4.16 ± 0.48 | 3.88 ± 0.37 |
Bil/tot (mg/dL) | 0.78 ± 0.13 | 0.81 ± 0.27 |
Bil/dir (mg/dL) | 0.12 ± 0.11 | 0.18 ± 0.14 |
ALP (UI/L) | 404.09 ± 154.90 | 515.97 ± 180.44 |
Table 2 Distribution of type and prevalence of mutations in study subjects n (%)
Type of mutations | Prevalence of mutations | ||
Control (26) | Case (31) | Total (57) | |
Normal | 20 (76.9) | 10 (32.3) | 30 (52.6) |
Abnormal MTHFRC677T | |||
Heterozygous | 6 (23.1) | 17 (54.8) | 23 (40.4) |
Homozygous | 0 (0) | 4 (12.9) | 4 (7.0) |
Table 3 Frequency of inherited thrombophilic abnormalities n (%)
Any thrombophilic factor | Control | Case | Total |
No | 25 (96.2) | 21 (67.7) | 46 (80.7) |
Yes | 1 (3.8) | 10 (32.3) | 11 (19.3) |
Total | 26 (100) | 31 (100) | 57 (100) |
Table 4 Frequency of thrombophilic disorders in children and adolescents with portal vein thrombosis n (%)
Study | Coagulation inhibitor protein deficit | Gene mutations | |||
PC | PS | FVL | PTHR | MTHFR | |
Dubuisson et al[13] (n = 20) | 9 (45) | 13 (65) | NP | NP | NP |
Uttenreuther-Fischer et al[2] (n = 23) | NP | NP | 2 (9) | NP | NP |
Heller et al[1] (n = 24) | NP | NP | 4 (17) | 0 | 1 (4) |
Pinto et al[12] (n = 14) | 6 (43) | 3 (21) | 0 | 1 (7) | 3 (21) |
Current study (n = 31) | 4 (13) | 4 (13) | 2 (6.5) | 3 (9.7) | 16 (67.7) |
- Citation: Pietrobattista A, Luciani M, Abraldes JG, Candusso M, Pancotti S, Soldati M, Monti L, Torre G, Nobili V. Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic thrombophilic disorders. World J Gastroenterol 2010; 16(48): 6123-6127
- URL: https://www.wjgnet.com/1007-9327/full/v16/i48/6123.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i48.6123