Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China

Table 1 Characteristics of studies included in meta-analysis

Authors	Origin	HWE of controls	n	Controls
Ding et al[13], 2009	Jiangsu	Yes	191	221
Guo et al[14], 2008	Gansu	Yes	80	480
Lee et al[15], 2008	Taiwan	Yes	406	656
Yang et al[16], 2007	Sichuan	Yes	191	198
Chen et al[17], 2006	Taiwan	Yes	330	592
Wu et al[18], 2005	Taiwan	Yes	134	237
Chao et al[19], 2000	Taiwan	Yes	88	105

HWE: Hardy-Weinberg equilibrium.

Table 2 Interaction between alcohol drinking and genotype for esophageal squamous cell carcinoma risk

	Non-drinker			Drinker
	Case/control	OR	95% CI	Case/control	OR	95% CI
ADH1B[13-15,17,18]
His/His + Arg/His	217/1355	Ref.	-	674/668	6.21	2.39-16.27
Arg/Arg	22/72	2.37	1.40-4.01	258/61	25.20	10.87-53.44
ALDH2[13-18]
Glu/Glu	96/604	Ref.	-	356/609	4.22	2.030-8.77
Glu/Lys + Lys/Lys	223/951	1.70	1.05-2.75	687/190	21.47	6.44-71.59

ADH1B: Alcohol dehydrogenase-1B; ALDH2: Aldehyde dehydrogenase-2; His: Histidine; Arg: Arginine; Glu: Glutamate; Lys: Lysine; OR: Odds ratio; CI: Confidence interval.

Table 3 Gene-gene interaction with alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 for esophageal squamous cell carcinoma risk

Genotype[13,15,18]	Case	Control	P value	OR	95% CI
Glu/Glu and His/His	134	299	Ref	-	-
Glu/Glu and Arg+	301	196	0.0001	3.66	1.66-6.74
Lys+ and His/His	82	69	0.005	2.72	1.34-5.51
Lys+ and Arg+1	181	50	0.003	7.09	2.16-23.33

¹Genotype data from[13,15,16,18]. His: Histidine; Arg: Arginine; Glu: Glutamate; Lys: Lysine; OR: Odds ratio; CI: Confidence interval.