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World J Gastroenterol. Dec 21, 2010; 16(47): 5975-5981
Published online Dec 21, 2010. doi: 10.3748/wjg.v16.i47.5975
Published online Dec 21, 2010. doi: 10.3748/wjg.v16.i47.5975
Table 1 Relationship between cyclooxygenase-2, Ki-67, cyclin A, p27 and clinicopathological characteristics of esophageal squamous cell carcinoma
Factors | n | COX-2 | P | Ki-67 | P | Cyclin A | P | p27 | P |
ESCC | 102 | 74.7 ± 61.2 | 0.00 | 64.0 ± 51.6 | 0.00 | 44.2 ± 32.2 | 0.00 | 182.0 ± 69.0 | 0.00 |
Normal | 28 | 30.2 ± 43.4 | 11.6 ± 2.3 | 11.7 ± 5.0 | 266.4 ± 28.0 | ||||
Age (yr) | |||||||||
≥ 60 | 44 | 77.8 ± 56.4 | NS | 66.7 ± 48.7 | NS | 44.6 ± 30.1 | NS | 185.4 ± 63.3 | NS |
< 60 | 58 | 70.6 ± 67.2 | 60.5 ± 55.6 | 43.6 ± 37.2 | 179 ± 73.3 | ||||
Gender | |||||||||
Male | 86 | 72.8 ± 62.0 | NS | 64.5 ± 51.3 | NS | 43.3 ± 32.5 | NS | 183.6 ± 68.1 | NS |
Female | 16 | 85.0 ± 57.6 | 61.5 ± 54.7 | 48.7 ± 37.3 | 173.1 ± 67.2 | ||||
Location | |||||||||
Upper | 11 | 59.5 ± 45.9 | NS | 49.6 ± 27.4 | NS | 48.3 ± 24.3 | NS | 205.4 ± 57.8 | NS |
Middle | 55 | 76.7 ± 62.2 | 63.3 ± 48.0 | 45.3 ± 37.0 | 181.5 ± 67.8 | ||||
Lower | 36 | 76.3 ± 64.6 | 69.6 ± 61.8 | 41.3 ± 29.7 | 175.5 ± 74.5 | ||||
Differentiation | |||||||||
Well | 32 | 68.7 ± 48.9 | NS | 43.8 ± 31.7 | 0.001 | 32.0 ± 19.0 | 0.03 | 206.2 ± 61.5 | 0.00 |
Moderate | 50 | 82.3 ± 63.0 | 63.2 ± 36.2 | 47.9 ± 27.8 | 189.9 ± 61.4 | ||||
Poor | 20 | 65.3 ± 74.0 | 98.4 ± 84.8 | 54.1 ± 53.7 | 123.5 ± 68.3 | ||||
T stage | |||||||||
T1-2 | 32 | 55.0 ± 42.3 | 0.028 | 70.2 ± 46.2 | NS | 40.6 ± 30.7 | NS | 169.3 ± 75.1 | NS |
T3-4 | 70 | 83.0 ± 66.5 | 61.2 ± 54.0 | 45.8 ± 34.4 | 187.8 ± 65.8 | ||||
N stage | |||||||||
N0 | 55 | 77.9 ± 65.2 | NS | 63.8 ± 49.8 | NS | 41.5 ± 28.4 | NS | 189.8 ± 63.4 | NS |
N1 | 47 | 70.9 ± 56.7 | 64.3 ± 54.2 | 47.4 ± 38.1 | 172.0 ± 74.7 | ||||
M stage | |||||||||
M0 | 85 | 74.3 ± 63.2 | NS | 63.9 ± 52.8 | NS | 41.8 ± 33.4 | NS | 181.7 ± 65.1 | |
M1 | 17 | 76.8 ± 52.0 | 64.7 ± 46.4 | 54.9 ± 30.4 | 183.2 ± 75.6 | ||||
Overall TNM stage | |||||||||
I | 5 | 62.8 ± 48.3 | NS | 56.0 ± 34.8 | NS | 38.4 ± 31.7 | NS | 201.2 ± 61.5 | NS |
II | 48 | 52.0 ± 40.5 | 75.7 ± 49.5 | 41.3 ± 29.6 | 187.3 ± 66.9 | ||||
III | 32 | 85.0 ± 66.5 | 59.3 ± 53.7 | 43.0 ± 39.4 | 170.3 ± 71.1 | ||||
IV | 17 | 81.5 ± 67.8 | 64.5 ± 55.3 | 55.9 ± 30.4 | 183.2 ± 75.6 |
Table 2 Correlation between expression of cyclooxygenase-2 and Ki-67, cyclin A and p27 in esophageal squamous cell carcinoma
- Citation: Huang JX, Xiao W, Chen WC, Lin MS, Song ZX, Chen P, Zhang YL, Li FY, Qian RY, Salminen E. Relationship between COX-2 and cell cycle-regulatory proteins in patients with esophageal squamous cell carcinoma. World J Gastroenterol 2010; 16(47): 5975-5981
- URL: https://www.wjgnet.com/1007-9327/full/v16/i47/5975.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i47.5975