Anti-pancreatic antibody in Turkish patients with inflammatory bowel disease and first-degree relatives

doi:10.3748/wjg.v16.i45.5732

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Dec 7, 2010 (publication date) through Mar 2, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2010; 16(45): 5732-5738
Published online Dec 7, 2010. doi: 10.3748/wjg.v16.i45.5732

Table 1 Characteristics of patients, relatives and control group subjects n (%)

	CD (n = 64)	CD relatives (n = 25)	UC (n = 63)	UC relatives (n = 28)	Control (n = 34)
Sex
Male	28 (43.8)	9 (36.0)	32 (50.8)	11 (39.3)	15 (44.1)
Female	36 (56.2)	16 (64.0)	31 (49.2)	17 (60.7)	19 (55.9)
Age (yr, mean ± SD)	37.93 ± 14.01	32.12 ± 14.31	38.74 ± 13.13	35.35 ± 17.07	38.58 ± 15.09
Disease duration (yr, mean ± SD)	4.37 ± 3.61		4.03 ± 3.66
Disease location (CD)
Colon	2 (3.1)
Ileum	26 (40.6)
Ileocolonic	36 (56.3)
Disease location (UC)
Proctitis			9 (14.3)
Distal involvement			24 (38.1)
Left colon invol			9 (14.3)
Diffuse			2 (3.2)
Pancolitis			19 (30.2)
Disease type (CD)
Stricturing	7 (10.9)
Penetrating	6 (9.4)
Inflammatory	51 (79.7)
Medications (for CD and UC)
No medication	5 (7.8)		5 (7.9)
5-ASA	57 (89.06)		57 (90.4)
Steroids	5 (7.8)		5 (7.9)
AZA	13 (20.3)		8 (12.6)
Antibiotics	1 (1.6)		3 (4.7)

CD: Crohn’s disease; UC: Ulcerative colitis; 5-ASA: 5-aminosalicylic acid; AZA: Azathioprine.

Table 2 Pancreatic antibody and anti-Saccharomyces cerevisiae positivity results in study groups n (%)

	CD (n = 64)	UC (n = 63)	CD relatives (n = 25)	UC relatives (n = 28)	Control (n = 34)
PAB	9 (14.1)	5 (7.9)	0 (0)	0 (0)	0 (0)
ASCA	37 (57.8)	13 (20.6)	9 (36)	5 (17.9)	6 (17.6)

CD: Crohn’s disease; UC: Ulcerative colitis; PAB: Anti-pancreatic antibody; ASCA: Anti-Saccharomyces cerevisiae.

Table 3 Positivity rates of pancreatic antibody according to Vienna classification

		A1 (n = 43, PAB = 7, 16.27%)				A2 (n = 21, PAB = 2, 9.52%)
		B1 (n = 31, PAB = 5, 16.12%)	B2 (n = 6, PAB = 1, 16.66%)	B3 (n = 6, PAB = 1, 16.66%)		B1 (n = 20, PAB = 2, 10%)	B2 (n = 1, PAB = 0, 0%)	B3 (n = 0, PAB = 0, 0%)
L1 (n = 26, 3.84%)	A1 (n = 18, PAB = 1, 5.55%)	n = 15, PAB = 1, 6.66%	n = 0, PAB = 0, 0%	n = 3, PAB = 0, 0%	A2 (n = 8, PAB = 0, 0%)	n = 7, PAB = 0, 0%	n = 1, PAB = 0, 0%	n = 0, PAB = 0, 0%
L2 (n = 2, 0%)	A1 (n = 1, PAB = 0, 0%)	n = 1, PAB = 0, 0%	n = 0, PAB = 0, 0%	n = 0, PAB = 0, 0%	A2 (n = 1, PAB = 0, 0%)	n = 1, PAB = 0, 0%	n = 0, PAB = 0, 0%	n = 0, PAB = 0, 0%
L3 (n = 36, 22.22%)	A1 (n = 24, PAB = 6, 25%)	n = 15, PAB = 4, 25%	n = 6, PAB = 1, 16.66%	n = 3, PAB = 1, 33.33%	A2 (n = 12, PAB = 2, 16.66%)	n = 12, PAB = 2, 16.66%	n = 0, PAB = 0, 0%	n = 0, PAB = 0, 0%

A1: Disease onset age < 40 yr; A2: Disease onset age ≥ 40 yr; B1: Inflammatory type; B2: Stricturizing type; B3: Fistulizing type; L1: Ileal involvement; L2: Colonic involvement; L3: Ileocolonic involvement. PAB: Pancreatic antibody.

Table 4 Positivity rates of anti-Saccharomyces cerevisiae according to Vienna classification

		A1 (n = 43, ASCA = 27, 62.79%)				A2 (n = 21, ASCA = 10, 47.61%)
		B1 (n = 31, ASCA = 18, 58.06%)	B2 (n = 6, ASCA = 3, 50%)	B3 (n = 6, ASCA = 6, 100%)		B1 (n = 20, ASCA = 9, 45%)	B2 (n = 1, ASCA = 1, 100%)	B3 (n = 0, ASCA = 0, 0%)
L1 (18/26, 69.23%)	A1 (n = 18, ASCA = 13, 72.22%)	n = 15, ASCA = 10, 66.66%	n = 0, ASCA = 0, 0%	n = 3, ASCA = 3, 100%	A2 (n = 8, ASCA = 5, 62.5%)	n = 7, ASCA = 4, 57.14%	n = 1, ASCA = 1, 100%	n = 0, ASCA = 0, 0%
L2 (0/2, 0%)	A1 (n = 1, ASCA = 0, 0%)	n = 1, ASCA = 0, 0%	n = 0, ASCA = 0, 0%	n = 0, ASCA = 0, 0%	A2 (n = 1, ASCA = 0, 0%)	n = 1, ASCA = 0, 0%	n = 0, ASCA = 0, 0%	n = 0, ASCA = 0, 0%
L3 (19/36, 52.77%)	A1 (n = 24, ASCA = 14, 58.33%)	n = 15, ASCA = 8, 53.33%	n = 6, ASCA = 3, 50%	n = 3, ASCA = 3, 100%	A2 (n = 12, ASCA = 5, 41.66%)	n = 12, ASCA = 5, 41.66%	n = 0, ASCA = 0, 0%	n = 0, ASCA = 0, 0%

Table 5 Pancreatic antibody and anti-Saccharomyces cerevisiae positivity according to Crohn’s disease activity index n (%)

Disease activity according to CDAI	PAB		ASCA		Total
Disease activity according to CDAI	Negative	Positive	Negative	Positive
Mild (< 150 points)	49 (84.5)	9 (15.5)	27 (46.6)	31 (53.4)	58 (100)
Moderate (150-450 points)	5 (100)	0 (0)	0 (0)	5 (100)	5 (100)
Severe (> 450 points)	1 (100)	0 (0)	0 (0)	1 (100)	1 (100)
Total	55	9	27	37	64

CDAI: Crohn’s disease activity index; PAB: Pancreatic antibody; ASCA: Anti-Saccharomyces cerevisiae.

Citation: Demirsoy H, Ozdil K, Ersoy O, Kesici B, Karaca C, Alkim C, Akbayir N, Erdem LK, Onuk MD, Beyzadeoglu HT. Anti-pancreatic antibody in Turkish patients with inflammatory bowel disease and first-degree relatives. World J Gastroenterol 2010; 16(45): 5732-5738
URL: https://www.wjgnet.com/1007-9327/full/v16/i45/5732.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i45.5732