Increased osteopontin and liver stiffness measurement by transient elastography in biliary atresia

Table 1 Biliary atresia patient characteristics (mean ± SD)

Variables	Controls (n = 10)	BA patients (n = 30)	P-value
Age (yr)	7.4 ± 3.9	7.2 ± 3.4	0.8
Gender (M:F)	4:6	13:17	0.5
Albumin (g/L)	-	43 ± 0.5	NA
Total bilirubin (mg/L)	-	28 ± 4.3	NA
Direct bilirubin (mg/L)	-	22 ± 4.3	NA
AST (IU/L)	-	129.4 ± 100.8	NA
ALT (IU/L)	-	119.4 ± 105.1	NA
ALP (IU/L)	-	469.9 ± 345.6	NA
Platelet count (103/mm3)	-	167.2 ± 96.3	NA
APRI	-	2.9 ± 2.9	NA
Osteopontin (ng/mL)	15.1 ± 15.0	47.0 ± 56.4	0.01
Liver stiffness (kPa)	3.9 ± 0.7	26.9 ± 24.6	0.001

BA: Biliary atresia; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; APRI: Aspartate aminotransferase to platelets ratio index; NA: Not applicable.

Table 2 Comparison of biliary atresia patients without and with jaundice (mean ± SD)

Variables	BA patients without jaundice (n = 16)	BA patients with jaundice (n = 14)	P-value
Age (yr)	7.3 ± 3.7	7.0 ± 3.1	0.9
Gender (M:F)	7:9	6:8	0.5
Albumin (g/L)	46 ± 0.3	39 ± 0.4	0.001
Total bilirubin (mg/L)	5 ± 0.2	55 ± 5.5	0.001
Direct bilirubin (mg/L)	2 ± 0.1	46 ± 5.5	0.003
AST (IU/L)	64.9 ± 46.9	203.1 ± 95.5	0.001
ALT (IU/L)	73.6 ± 61.2	171.8 ± 121.5	0.01
ALP (IU/L)	287.9 ± 116.8	677.9 ± 404.1	0.001
Platelet count (103/mm3)	215.8 ± 81.3	111.6 ± 81.0	0.002
APRI	0.8 ± 0.8	5.1 ± 2.7	< 0.001
Osteopontin (ng/mL)	11.9 ± 6.1	87.1 ± 61.6	0.001
Liver stiffness (kPa)	8.7 ± 3.0	47.7 ± 21.8	0.001

BA: Biliary atresia; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; APRI: Aspartate aminotransferase to platelets ratio index.