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©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 14, 2010; 16(42): 5380-5387
Published online Nov 14, 2010. doi: 10.3748/wjg.v16.i42.5380
Published online Nov 14, 2010. doi: 10.3748/wjg.v16.i42.5380
Table 1 Univariate analysis of factors affecting overall survival of 53 gastric cancer patients by Kaplan - Meier method
Factor | n | 5-yr survival rate (%) | χ2 | P value |
Gender | 0.217 | 0.641 | ||
Male | 37 | 45.9 | ||
Female | 16 | 43.8 | ||
Age at surgery (yr) | 0.260 | 0.610 | ||
< 65 | 40 | 42.5 | ||
≥ 65 | 13 | 53.8 | ||
Tumor size (cm) | 5.711 | 0.017 | ||
< 4 | 13 | 76.9 | ||
≥ 4 | 40 | 35.0 | ||
Tumor location | 2.619 | 0.270 | ||
Lower stomach | 28 | 57.1 | ||
Middle stomach | 18 | 33.3 | ||
Upper stomach | 7 | 28.6 | ||
Depth of primary tumor invasion | 3.089 | 0.079 | ||
T1 + T2 | 6 | 83.3 | ||
T3 + T4 | 47 | 40.4 | ||
Status of lymph node metastasis | 17.950 | < 0.001 | ||
Negative | 16 | 93.8 | ||
Positive | 37 | 24.3 | ||
Lauren’s classification | 3.280 | 0.070 | ||
Intestinal | 25 | 60.0 | ||
Diffuse | 28 | 32.1 | ||
STAT3 | 19.432 | < 0.001 | ||
Negative | 22 | 81.8 | ||
Positive | 31 | 19.4 | ||
pSTAT3 | 40.444 | < 0.001 | ||
Negative | 27 | 85.2 | ||
Positive | 26 | 3.8 | ||
SOCS-1 | 5.712 | 0.017 | ||
Negative | 47 | 38.3 | ||
Positive | 6 | 100.0 | ||
Survivin | 4.295 | 0.038 | ||
Negative | 14 | 71.4 | ||
Positive | 39 | 35.9 | ||
Bcl-2 | 13.866 | < 0.001 | ||
Negative | 27 | 70.4 | ||
Positive | 26 | 19.2 |
Table 2 Multivariate analysis of factors affecting overall survival of 53 gastric cancer patients by Cox proportional hazards model
Factors | P value | Relative risk | 95% CI |
Status of lymph node metastasis | 0.040 | 8.591 | 1.104-66.858 |
Tumor size | 0.701 | ||
STAT3 | 0.225 | ||
pSTAT3 | < 0.001 | 9.605 | 3.107-29.694 |
SOCS-1 | 0.429 | ||
Survivin | 0.749 | ||
Bcl-2 | 0.213 |
- Citation: Deng JY, Sun D, Liu XY, Pan Y, Liang H. STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer. World J Gastroenterol 2010; 16(42): 5380-5387
- URL: https://www.wjgnet.com/1007-9327/full/v16/i42/5380.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i42.5380