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World J Gastroenterol. Nov 7, 2010; 16(41): 5241-5246
Published online Nov 7, 2010. doi: 10.3748/wjg.v16.i41.5241
Published online Nov 7, 2010. doi: 10.3748/wjg.v16.i41.5241
Table 1 Clinical profiles of 42 patients with autoimmune pancreatitis
Patient | Sex | Age (yr) | IgE (< 171 U/mL) | IgG (870-1800 mg/dL) | IgG4 (< 135 mg/dL) | Total bilirubin (0.3-1.3 mg/dL) | Concomitant allergic diseases | Extrapancreatic lesion associated with AIP |
1 | F | 58 | 670 | 2542 | 592 | 0.6 | AR | - |
2 | M | 63 | 650 | 2055 | 691 | 3.0 | AR | - |
3 | F | 53 | 500 | 1527 | 143 | 7.9 | AR | SA |
4 | M | 64 | 490 | 2457 | 670 | 0.5 | BA | - |
5 | M | 56 | 1800 | 1712 | 436 | 0.5 | BA | - |
6 | F | 43 | 340 | 1036 | 223 | 0.9 | BA | - |
7 | M | 74 | 2339 | 1481 | 98 | 0.9 | Urticaria | RF |
8 | F | 70 | 480 | 2190 | 133 | 5.8 | - | - |
9 | M | 57 | 120 | 3793 | 1420 | 10.6 | - | RF |
10 | M | 55 | 480 | 1419 | 320 | 1.7 | - | - |
11 | M | 61 | 270 | 1878 | 410 | 0.4 | - | SC |
12 | M | 66 | 1200 | 1620 | 310 | 0.5 | - | SA |
13 | M | 79 | 170 | 1585 | 420 | 3.3 | - | SC |
14 | M | 73 | 290 | 1647 | 360 | 5.4 | - | - |
15 | M | 79 | 410 | 1404 | 554 | 0.7 | - | - |
16 | M | 76 | 1000 | 1728 | 65 | 14.1 | - | SC |
17 | F | 72 | 650 | 2384 | 1400 | 1.6 | - | SA |
18 | F | 65 | 190 | 1511 | 374 | 0.6 | - | - |
19 | M | 68 | 290 | 1656 | 253 | 2.0 | - | SC |
20 | M | 61 | 940 | 1448 | 578 | 1.6 | - | - |
21 | F | 61 | 640 | 2177 | 354 | 0.4 | - | - |
22 | M | 58 | 2289 | 1973 | 481 | 6.9 | - | - |
23 | M | 71 | 1915 | 2318 | 470 | 0.6 | - | - |
24 | M | 61 | 69 | 2215 | 974 | 0.5 | - | SA |
25 | M | 65 | 91 | 3032 | 1260 | 5.4 | - | SC, RF |
26 | M | 64 | 330 | 1730 | 361 | 0.4 | - | SC |
27 | M | 66 | 1330 | 1849 | 270 | 4.7 | - | - |
28 | F | 64 | 328 | 2898 | 456 | 12.8 | - | SC |
29 | M | 69 | 440 | 1875 | 270 | 8.7 | - | - |
30 | M | 73 | 70.3 | 2395 | 393 | 0.4 | - | RF |
31 | M | 67 | 660 | 1683 | 230 | 0.6 | - | - |
32 | M | 72 | 3000 | 1579 | 455 | 0.5 | - | - |
33 | M | 61 | 467 | 1301 | 331 | 2.9 | - | - |
34 | M | 40 | 320 | 1996 | 650 | 1.0 | - | RF |
35 | M | 62 | 480 | 1368 | 236 | 0.5 | - | SC, SA |
36 | M | 71 | 267 | 1827 | 458 | 1.3 | - | - |
37 | M | 59 | 625 | 1876 | 139 | 0.5 | - | RF |
38 | M | 73 | 302 | 2834 | 1800 | 0.5 | - | SA |
39 | F | 76 | 426 | 1458 | 543 | 0.9 | - | RF |
40 | M | 76 | 943 | 1840 | 431 | 0.7 | - | SC |
41 | M | 59 | 67 | 1338 | 140 | 0.7 | - | - |
42 | M | 64 | 198 | 1709 | 232 | 10.2 | - | - |
Table 2 Correlations between IgG, IgG4, and IgE
Correlation coefficient | P value | |
IgG and IgE | -0.168 | 0.290 |
IgG4 and IgE | -0.188 | 0.235 |
IgG and IgG4 | 0.698 | < 0.0001 |
Table 3 Comparison of IgE, IgG, and IgG4 between patients with and without extrapancreatic lesions
Patients with extrapancreatic lesions (n = 20) | Patients without extrapancreatic lesions (n = 22) | P value | |
IgE (IU/mL) | 526 ± 531 | 819 ± 768 | 0.163 |
IgG (mg/dL) | 2065 ± 644 | 1775 ± 396 | 0.093 |
IgG4 (mg/dL) | 588 ± 505 | 392 ± 161 | 0.110 |
Table 4 Comparison of IgE, IgG, and IgG4 between patients with and without clinical relapses
Patients with clinical relapses (n = 5) | Patients without clinical relapses (n = 28) | P value | |
IgE (IU/mL) | 457 ± 346 | 784 ± 786 | 0.374 |
IgG (mg/dL) | 1898 ± 424 | 1915 ± 579 | 0.953 |
IgG4 (mg/dL) | 266 ± 157 | 558 ± 429 | 0.148 |
Table 5 Transition of IgE, IgG, and IgG4 before and after steroid treatment
Before | After | P value | |
IgE (IU/mL) (n = 29) | 723 ± 744 | 673 ± 660 | 0.633 |
Proportion of high IgE | 26/29 | 23/29 | 0.470 |
IgG (mg/dL) (n = 30) | 1891 ± 566 | 1155 ± 315 | < 0.0001 |
Proportion of high IgG | 14/30 | 1/30 | 0.0002 |
IgG4 (mg/dL) (n = 28) | 557 ± 429 | 229 ± 112 | 0.0002 |
Proportion of high IgG4 | 27/28 | 20/28 | 0.0248 |
- Citation: Hirano K, Tada M, Isayama H, Kawakubo K, Yagioka H, Sasaki T, Kogure H, Nakai Y, Sasahira N, Tsujino T, Toda N, Koike K. Clinical analysis of high serum IgE in autoimmune pancreatitis. World J Gastroenterol 2010; 16(41): 5241-5246
- URL: https://www.wjgnet.com/1007-9327/full/v16/i41/5241.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i41.5241