Clinical analysis of high serum IgE in autoimmune pancreatitis

Table 1 Clinical profiles of 42 patients with autoimmune pancreatitis

Patient	Sex	Age (yr)	IgE (< 171 U/mL)	IgG (870-1800 mg/dL)	IgG4 (< 135 mg/dL)	Total bilirubin (0.3-1.3 mg/dL)	Concomitant allergic diseases	Extrapancreatic lesion associated with AIP
1	F	58	670	2542	592	0.6	AR	-
2	M	63	650	2055	691	3.0	AR	-
3	F	53	500	1527	143	7.9	AR	SA
4	M	64	490	2457	670	0.5	BA	-
5	M	56	1800	1712	436	0.5	BA	-
6	F	43	340	1036	223	0.9	BA	-
7	M	74	2339	1481	98	0.9	Urticaria	RF
8	F	70	480	2190	133	5.8	-	-
9	M	57	120	3793	1420	10.6	-	RF
10	M	55	480	1419	320	1.7	-	-
11	M	61	270	1878	410	0.4	-	SC
12	M	66	1200	1620	310	0.5	-	SA
13	M	79	170	1585	420	3.3	-	SC
14	M	73	290	1647	360	5.4	-	-
15	M	79	410	1404	554	0.7	-	-
16	M	76	1000	1728	65	14.1	-	SC
17	F	72	650	2384	1400	1.6	-	SA
18	F	65	190	1511	374	0.6	-	-
19	M	68	290	1656	253	2.0	-	SC
20	M	61	940	1448	578	1.6	-	-
21	F	61	640	2177	354	0.4	-	-
22	M	58	2289	1973	481	6.9	-	-
23	M	71	1915	2318	470	0.6	-	-
24	M	61	69	2215	974	0.5	-	SA
25	M	65	91	3032	1260	5.4	-	SC, RF
26	M	64	330	1730	361	0.4	-	SC
27	M	66	1330	1849	270	4.7	-	-
28	F	64	328	2898	456	12.8	-	SC
29	M	69	440	1875	270	8.7	-	-
30	M	73	70.3	2395	393	0.4	-	RF
31	M	67	660	1683	230	0.6	-	-
32	M	72	3000	1579	455	0.5	-	-
33	M	61	467	1301	331	2.9	-	-
34	M	40	320	1996	650	1.0	-	RF
35	M	62	480	1368	236	0.5	-	SC, SA
36	M	71	267	1827	458	1.3	-	-
37	M	59	625	1876	139	0.5	-	RF
38	M	73	302	2834	1800	0.5	-	SA
39	F	76	426	1458	543	0.9	-	RF
40	M	76	943	1840	431	0.7	-	SC
41	M	59	67	1338	140	0.7	-	-
42	M	64	198	1709	232	10.2	-	-

AIP: Autoimune pancreatitis; AR: Allergic rhinitis; BA: Bronchial asthma; SA: Sialadenitis; RF: Retroperitoneal fibrosis; SC: Sclerosing cholangitis.

Table 2 Correlations between IgG, IgG4, and IgE

	Correlation coefficient	P value
IgG and IgE	-0.168	0.290
IgG4 and IgE	-0.188	0.235
IgG and IgG4	0.698	< 0.0001

Table 3 Comparison of IgE, IgG, and IgG4 between patients with and without extrapancreatic lesions

	Patients with extrapancreatic lesions (n = 20)	Patients without extrapancreatic lesions (n = 22)	P value
IgE (IU/mL)	526 ± 531	819 ± 768	0.163
IgG (mg/dL)	2065 ± 644	1775 ± 396	0.093
IgG4 (mg/dL)	588 ± 505	392 ± 161	0.110

Table 4 Comparison of IgE, IgG, and IgG4 between patients with and without clinical relapses

	Patients with clinical relapses (n = 5)	Patients without clinical relapses (n = 28)	P value
IgE (IU/mL)	457 ± 346	784 ± 786	0.374
IgG (mg/dL)	1898 ± 424	1915 ± 579	0.953
IgG4 (mg/dL)	266 ± 157	558 ± 429	0.148

Table 5 Transition of IgE, IgG, and IgG4 before and after steroid treatment

	Before	After	P value
IgE (IU/mL) (n = 29)	723 ± 744	673 ± 660	0.633
Proportion of high IgE	26/29	23/29	0.470
IgG (mg/dL) (n = 30)	1891 ± 566	1155 ± 315	< 0.0001
Proportion of high IgG	14/30	1/30	0.0002
IgG4 (mg/dL) (n = 28)	557 ± 429	229 ± 112	0.0002
Proportion of high IgG4	27/28	20/28	0.0248

Normal range, IgE: < 171 IU/mL, IgG: 870-1800 mg/dL, IgG: < 135 mg/dL.