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Copyright ©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 28, 2010; 16(40): 5024-5034
Published online Oct 28, 2010. doi: 10.3748/wjg.v16.i40.5024
Table 1 Summary of included articles for health related quality of life in ulcerative colitis
StudyPatient populationHRQOL instrumentsStudy conclusions
Cohen et al[2]Steroid-refractory UC patients treated with CSA vs colectomyIBDQ visual-analog scale, OreslandCSA patients had similar HRQOL compared to colectomy group. CSA can be alternative to surgery in selected patients
Sagar et al[13]UC patients after IPAA vs UC patients on long-term medical treatmentbased on a questionnaire by Oresland et alHRQOL after IPAA is no worse than that of patients with long-standing UC on medical treatment in remission
Camilleri-Brennan et al[15]UC patients with TPC and EI vs general populationSF-36 version 2 (SF-36II)HRQOL of TPS and EI patients very similar to that of the general population. TPC and EI remains a viable option for patients with UC
da Luz Moreira et al[18]UC patients with IRA vs IPAACGQLHRQOL similar between groups, but IRA is inferior to IPAA because of dietary and work restrictions
Nessar et al[20]CI (Kock) vs EICGQLHRQOL significantly better with CI, but complications are common in CI group
Berndtsson et al[21]UC patients before and after IPAAGQL, VAS, OAS open ended questionsIPAA had no impact on HRQOL, but improved relations with friends, freedom in role function, and body image reduced the negative effects caused by colitis or life with ileostomy.
Michelassi et al[22]10 yr prospective study of UC patients with IPAATwo part questionnaireExcellent long term functional outcomes after double stapled IPAA
Fazio et al[23]UC patients with IPAASF 36 CGQLHRQOL increase following IPAA; no deterioration with time.
Lian et al[25]UC patients with hand sewn vs stapled IPAA complicated by anastomotic leakCGQLFunctional outcomes following anastomotic leak better in stapled IPAA compared to handsewn IPAA
Scarpa et al[26]UC patients, UC patients after IPAA, and normal controlsItalian CGQL vs PIBDQLPIBDQL has significantly better discriminative ability compared to the Italian CGQL
Gearhart et al[27]UC female patients with sphincter defectsFISI, FIQL Wexner scoreIPAA can provide a satisfactory HRQOL in patients with sphincter defect who are fully continent preoperatively
Lepistö et al[28]HRQOL after pouch failure vs well functioning IPAASF-36IPAA failure group with significantly lower scores for physical function, energy level, and physical role function
Tan et al[29]UC patients following pouch excision vs initial TPC and EISF-36HRQOL similar between the pouch excision and initial IPAA groups
Baixauli et al[30]IPAA patients with pouch failureCGQLCD is common cause of pouch failure. HRQOL similar in UC or CD pouch failure patients
Delaney et al[31]IPAA patients 70 yr and olderCGQLGood HRQOL, health, levels of energy and happiness. However, IPAA associated with high rate of morbidity and mortality
Lillehei et al[32]Pediatric UC patients with IPAAStandardized questionnaireExcellent functional outcomes. High rate of pouchitis
Fichera et al[33]Laparoscopic vs open IPAATwo part questionnaireHRQOL was similar between the groups. Better patient acceptance and improved cosmesis in laparoscopic IPAA
Larson et al[34]Laparoscopic vs open IPAAFSFI, IIEF body and cosmetic evaluationHRQOL comparable between open and laparoscopic patients
Dunker et al[35]Laparoscopic vs open IPAABody image questionnaireHRQOL similar between groups
Davies et al[36]Prospective evaluation of sexual function before and after IPAAFSFI, IIEDFImproved sexual function in women. Unchanged sexual function in men
Ording Olsen et al[38]Reproductive health of women with UC undergoing IPAA vs UC vs general populationSignificant decrease in fecundity (36% vs 80%-90%) following IPAA compared to UC and general population
Hahnloser et al[39]Pregnancy following IPAA vs general populationNo increase in pregnancy complications following IPAA. Vaginal delivery not contraindicated