Liver stiffness measurements in patients with HBV vs HCV chronic hepatitis: A comparative study

Table 1 Mean values of liver stiffness according to fibrosis stage in patients with hepatitis B virus vs hepatitis C virus chronic hepatitis

Category	Hepatitis B virus		Hepatitis C virus		P
	Cases	Mean values of LS (kPa)	Cases	Mean values of LS (kPa)
Total cases	140	8.1 ± 4.2	317	8.9 ± 5.2	0.395 (NS)
F = 0	1	7.4	5	5.2 ± 0.7	-
F = 1	32	6.5 ± 1.9	34	5.8 ± 2.1	0.0889 (NS)
F = 2	67	7.1 ± 2	146	6.9 ± 2.5	0.3369 (NS)
F = 3	33	9.1 ± 3.6	93	9.9 ± 5	0.7038 (NS)
F = 4	7	19.8 ± 8.6	39	17.3 ± 6.1	0.6574 (NS)

F: Fibrosis; LS: Liver stiffness; NS: Not statistically significant.

Table 2 Predictive value of liver stiffness for the presence of significant fibrosis (F2), severe fibrosis (F3) and cirrhosis (F4) in hepatitis B virus vs hepatitis C virus patients

Parameter	Hepatitis B virus			Hepatitis C virus			All
	F2	F3	F4	F2	F3	F4	F2	F3	F4
AUROC	0.658	0.753	0.974	0.750	0.797	0.933	0.712	0.786	0.943
Cut-off (kPa)	7	8.8	13.6	6.8	8.6	13.3	6.9	8.7	13.6
Sensitivity (%)	59	53	86	60	62	77	59	60	74
Specificity (%)	70	85	99	88	81	93	78	83	95
PPV (%)	86	58	78	97	71	61	93	68	64
NPV (%)	39	82	99	23	75	96	26	77	97

AUROC: Area under the receiver operating characteristics curve; PPV: Positive predictive value; NPV: Negative predictive value.

Table 3 Cut-off values for different stages of fibrosis in patients with hepatitis B virus chronic hepatitis, proposed by various authors (kPa)

Fibrosis	Marcellin et al[17]	Chang et al[33]	Chan et al[34]	Kim et al[35]
F0	5.1	6.9	5.9	-
F1	6.0	12.2	5.9	9.1
F2	7.0	-	7.0	-
F3	12.8	24.8	8.8	-
F4	23.7	-	14.2	14.0