HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication

Table 1 Clinical characteristics of subjects

	Total patients (n = 488)	Atrophic gastritis (n = 160)	Gastric cancer (n = 73)	Controls (n = 255)
Mean age (SD, yr)	48.6 (11.9)	51.4 (10.6)	59.6 (11.2)	43.6 (10.3)
Gender (%)
Male	57.2	48.7	65.8	60.0
Female	42.8	51.3	34.2	40.0
Smoking (%)
None	69.4	75.6	52.1	70.5
Mild/moderate	21.4	19.4	30.1	20.0
Severe	9.2	5.0	17.8	9.5
Alcohol (%)
None	61.6	68.8	41.1	63.0
Mild/moderate	28.1	25.6	41.1	26.0
Severe	10.3	5.6	17.8	11.0
HOGG1 (%)
Ser/Ser	24.5	16.7	28.8	28.2
Ser/Cys	47.0	35.3	25.8	46.7
Cys/Cys	28.5	48.0	45.4	25.1

HOGG1: Human oxoguanine glycosylase 1.

Table 2 Clinical characteristics of different grades of atrophic gastritis

	Grade 1 (n = 68)	Grade 2 (n = 68)	Grade 3 (n = 23)
Mean age (SD, yr)	51.3 (10.8)	51.1 (9.8)	52.9 (12.8)
Gender (%)
Male	47.1	50.0	52.2
Female	53.9	50.0	47.8
Smoking (%)
None	76.5	75.0	73.9
Mild/moderate	16.2	20.6	26.1
Severe	7.3	4.4	0.0
Alcohol (%)
None	70.6	64.7	73.9
Mild/moderate	22.1	29.4	26.1
Severe	7.3	5.9	0.0
HOGG1 (%)
Ser/Ser	18.2	15.1	13.0
Ser/Cys	62.1	36.4	43.5
Cys/Cys	19.7	48.5	43.5

HOGG1: Human oxoguanine glycosylase 1.

Table 3 Clinical characteristics of different grades of intestinal metaplasia

	Grade 1 (n = 44)	Grade 2 (n = 76)	Grade 3 (n = 40)
Mean age (SD, yr)	50.7 (9.5)	51.4 (11.2)	51.9 (10.1)
Gender (%)
Male	47.7	48.7	50.0
Female	52.3	51.3	50.0
Smoking (%)
None	86.4	71.1	72.5
Mild/moderate	6.8	25.0	22.5
Severe	6.8	3.9	5.0
Alcohol (%)
None	77.3	60.5	75.0
Mild/moderate	15.9	32.9	22.5
Severe	6.8	6.6	2.5
HOGG1 (%)
Ser/Ser	13.9	18.6	15.8
Ser/Cys	53.5	42.7	52.6
Cys/Cys	32.6	38.7	31.6

HOGG1: Human oxoguanine glycosylase 1.

Table 4 Odds ratios for association of genotypes and gastric cancer/atrophic gastritis

HOGG1 subtypes	Gastric cancer vs control		Atrophic gastritis vs control
	OR (95% CI)	Adjusted OR (95% CI)1	OR (95% CI)	Adjusted OR (95% CI)1
Ser/ser	1	1	1	1
Ser/Cys	0.96 (0.51-1.84)	1.29 (0.57-2.93)	1.76 (1.03-3.0)	2.05 (1.14-3.68)
Cys/Cys	1.1 (0.48-2.10)	1.22 (0.48-3.14)	2.38 (1.34-4.23)	2.76 (1.47-5.18)

¹Adjusted for age, gender, other risk factors such as alcohol and smoking. HOGG1: Human oxoguanine glycosylase 1; OR: Odds ratios.