Mapping of liver-enriched transcription factors in the human intestine

Table 1 Patient characteristics

Patient	Sex	Age (yr)	Tumor localization	Tumor type	TNM classification	UICC classification
CN2/CP2	M	64	Rectum	Colorectal cancer	pT2 pN0 M0-G2	I
CN3/CP3	F	74	Colon transversum	Colorectal cancer	pT2 pN1 pM1-G2	IV
CN7/CP7	F	51	Colon ascendens	Colorectal cancer	pT3 pN2 M0-G2	III
CN8/CP8	M	81	Colon sigmoideum	Colorectal cancer	pT3 pN0 M0-G3	II
CN9/CP9	F	63	Colon sigmoideum	Colorectal cancer	pT2 pN1 M0-G2	III
CN10/CP10	M	81	Rectum	Colorectal cancer	pT3 pN1 M0-G2	III
CN11/CP11	F	49	Colon ascendens	Colorectal cancer	pT3 pN2 M1-G2	IV
CN15/CP15	M	73	Colon sigmoideum	Colorectal cancer	pT4 pN0 M0-G3	II
CN16/CP16	M	72	Rectum	Colorectal cancer	pT2 pN0 M0-G2	I
CN17/CP17	M	44	Rectum	Colorectal cancer	pT2 pN1 M1-G2	IV
CN18/CP18	F	67	Rectum	Colorectal cancer	pT3 pN1 M1-G2	IV
CN19/CP19	M	61	Rectum	Colorectal cancer	pT2 pN2 M1-G2	IV
CN20/CP20	M	56	Rectum	Colorectal cancer	pT3 pN0 M0-G2	II
CN21/CP21	M	61	Colon sigmoideum	Colorectal cancer	pT3 pN2 M1-G2	IV
P34 CN/CP	F	61	Colon sigmoideum	Colorectal cancer	pT4 pN1 M1-G2	IV
P38 CN/CP	M	67	Rectum	Colorectal cancer	pT2 pN0 M0-G3	I
Duo P39	M	72	Pancreas	Pancreatic carcinoma
Duo P44	F	66	Pancreas	Pancreatic cyst
Duo P47	F	57	Pancreas	Pancreatic carcinoma
Jej P41	M	53	Pancreas	Pancreatic carcinoma
Jej P44	F	66	Pancreas	Pancreatic cyst
Jej P45	M	61	Pancreas	Bile duct cancer
Ileum P40	F	78	Colon ascendens	Colorectal cancer
Ileum P43	M	78	Colon ascendens	Colorectal cancer
Ileum P46	M	64	Colon ascendens	Colorectal cancer

Table 2 Expression pattern of liver-enriched transcription factors in the human intestine

	Duodenum	Jejunum	Ileum	Colon
HNF1	++	+++	++	+
HNF1α	++	+++	+++	+
HNF1β	+	-	+	++
FOXA2	+	++	-	++
HNF4	++	+++	++	+
HNF4α	+	+++	++	+
HNF4γ	++	++	++	+
HNF6	++	+	-	-
C/EBPα	+	+++	++	+
C/EBPγ	+	+++	++	+
MitATPase	++	++	++	++
PPARα	++	+	++	++
IGFβ	+	-	+	++
AHR	+	+	+	++
NGN3	+	+++	++	+
ALDH3A1	+	+++	-	+
ADH1A1	++	+	++	+
COL5A1	++	+	+	+
CYP51	++	++	++	+
UGT1A1	+++	+++	+	++
HSP105B	++	++	+	++
CDP	+	+	+	++
GATA4	++	+++	-	-

+++: Very strong expression; ++: Strong expression; +: Detectable; -: Not detectable. HNF: Hepatocyte nuclear factor; EBP: Enhancer binding protein.