Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas

Table 1 Baseline characteristics of the study subjects

Variable	Male	Female	P
n	3906	5405
Age (yr)	54 (48, 61)	52 (47, 59)	< 0.001
Smoke, n (%)	884 (22.6)	49 (0.9)	< 0.001
Alcohol, n (%)	876 (22.4)	119 (2.2)	< 0.001
Body weight (kg)	67.6 (61.8, 74.2)	56.0 (51.3, 61.7)	< 0.001
Body fat (%)	22.7 (19.4, 26.1)	30.6 (26.8, 34.9)	< 0.001
Systolic BP (mmHg)	128 (116, 141)	122 (111, 138)	< 0.001
Diastolic BP (mmHg)	81 (73, 88)	74 (66, 82)	< 0.001
Hypertension, n (%)	1518 (38.9)	1575 (29.1)	< 0.001
Diabetes, n (%)	317 (8.1)	330 (6.1)	< 0.001
Glucose AC (mg/dL)	90 (84, 97)	88 (83, 95)	< 0.001
TCH (mg/dL)	191 (168, 215)	190 (169, 215)	0.448
WBC (× 103/μL)	6.31 (5.38, 7.42)	5.90 (5.02, 6.97)	< 0.001
Lymphocyte (%)	32.2 (27.0, 37.4)	33.9 (28.7, 39.2)	< 0.001
MS, n (%)	755 (19.3)	982 (18.2)	0.154
H. pylori, n (%)	1571 (40.2)	2083 (38.5)	0.096
Adenoma, n (%)	1053 (27.0)	870 (16.1)	< 0.001

n: Subject number; BP: Blood pressure; TCH: Total plasma cholesterol; WBC: White blood cell; H. pylori: Helicobacter pylori; MS: Metabolic syndrome.

Table 2 Multivariate logistic regression analysis of the risk factors for colorectal adenomas

Variable	β	SE	P	OR	95% CI
Intercept	-5.031	0.253	< 0.001	-	-
Gender (M vs F)	0.696	0.072	< 0.001	2.005	1.740-2.310
Age (per year)	0.045	0.003	< 0.001	1.046	1.040-1.052
Smoke (yes vs no)	0.320	0.094	0.001	1.377	1.146-1.654
Alcohol (yes vs no)	-0.010	0.093	0.915	0.990	0.826-1.187
Body fat (%)	0.016	0.005	0.001	1.016	1.007-1.026
WBC (per 103/μL)	0.038	0.017	0.025	1.038	1.005-1.073
H. pylori (yes vs no)	0.312	0.054	< 0.001	1.366	1.230-1.517
MS (yes vs no)	0.342	0.068	< 0.001	1.408	1.231-1.610

WBC: White blood cell; H. pylori: Helicobacter pylori; MS: Metabolic syndrome; OR: Odd ratio; CI: Confidence interval.