Pulmonary involvement and allergic disorders in inflammatory bowel disease

Table 1 Studies on the relationship between IBD and atopic features

Group	Protocol	Atopy history	Skin prick tests	IgE	Ref.
CD: 11	Skin prick tests	Allergic symptoms were more prevalent in IBD vs controls P < 0.007 (in UC P < 0.004)	IBD vs control P < 0.02	No statistically significant differences	[109]
UC: 19	SIgE
Normals: 16	Atopy history
UC: 14	IgA, IgG, IgM	-	-	Increased IgG, IgM and IgE in patients vs controls (P < 0.01)	[114]
CD: 20	IgE
Controls: 72
UC: 300	Questionnaire	Asthma, hay fever, allergic rhinitis; UC vs Controls: P < 0.02; CD vs Controls: NS; Eczema-Any atopy-Family history; Both UC & CD vs controls: P < 0.001	-	-	[117]
CD: 200
Controls: 254
UC: 39	Skin prick tests to various common allergens	23.1% in UC; 22.9% in CD; 21.4% in disease controls; 20% among healthy subjects	14/39 in UC and 12/35 in CD in food allergens (P < 0.001)	No differences	[119]
CD: 35
Healthy: 37
UC: 39	Skin prick tests to milk proteins	Positive: 15.7% of UC and 13.3% of CD; Significant difference between patients and healthy subjects	No differences	No differences	[120]
CD: 19
Normals: 20
UC: 63	Skin prick tests to various common allergens	No difference between patients and healthy subjects	No difference between patients and healthy subjects	No difference between patients and healthy subjects	[121]
CD: 59
Controls: 103
CD: 308	Questionnaire	Atopic disease was more common in CD vs normal (P = 0.001); Atopic eczema was twice as common in CD vs normal (P = 0.001)	-	-	[124]
Normals: 930
UC: 50	Skin prick/patch tests to airborne, food, contact allergens	Allergic symptoms were more prevalent in UC and first degree relatives than in controls (P < 0.0001, P = 0.008)	UC vs controls; Immediate type hypersensitivity P = 0.01; Delayed type hypersensitivity P = 0.03	IgE levels were higher in UC than in controls P = 0.02	[125]
Healthy: 50	SIgE
	Atopy history and family history

IBD: Inflammatory bowel disease; CD: Crohn’s disease; UC: Ulcerative colitis.