Hepatic tight junctions: From viral entry to cancer metastasis

doi:10.3748/wjg.v16.i3.289

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2010; 16(3): 289-295
Published online Jan 21, 2010. doi: 10.3748/wjg.v16.i3.289

Table 1 Clinical significance of TJ molecules in human HCC

Molecules	Expression in HCC¹	Clinical correlations	Ref.
CAR	Reduced	Poor tumor differentiation	[64]
Claudin-1	Reduced	Poor tumor differentiation, tumor invasion, poor survival	[63]
Claudin-10	Higher	Tumor recurrence	[67]
Occludin	Reduced	-	[9]
Symplekin	Reduced	Poor tumor differentiation	[3]
ZO-1	Reduced	-	[9]

¹Relative expression of TJ molecules in HCC tissues compared to normal or adjacent non-tumor tissues. TJ: Tight junction; HCC: Hepatocellular carcinoma; CAR: Coxsackievirus and adenovirus receptor.

Citation: Lee NP, Luk JM. Hepatic tight junctions: From viral entry to cancer metastasis. World J Gastroenterol 2010; 16(3): 289-295
URL: https://www.wjgnet.com/1007-9327/full/v16/i3/289.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i3.289