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©2010 Baishideng.
World J Gastroenterol. Jun 28, 2010; 16(24): 3016-3024
Published online Jun 28, 2010. doi: 10.3748/wjg.v16.i24.3016
Published online Jun 28, 2010. doi: 10.3748/wjg.v16.i24.3016
Table 1 Main demographic and clinical characteristics of liver transplant recipients (n = 240) according to the presence (n = 80, 33.3%) or absence (n = 160, 66.7%) of HCC
HCC present (n = 80) | HCC absent (n = 160) | P value | ||
Male gender | 178 (74.2) | 70 | 108 | < 0.0010 |
Age1 (yr) | 55 (22-68) | 57.2 ± 5.9 | 52.0 ± 8.6 | < 0.0001 |
Body mass index1 (kg/m2) | 25.2 (14.8-48.5) | 26.4 ± 4.2 | 24.7 ± 3.3 | < 0.0010 |
Etiology | ||||
Viral (n = 137) | 50 | 87 | NS | |
HBV | 37 (15.4) | |||
HCV | 100 (41.7) | |||
Alcoholic | 103 (42.9) | |||
Child-Pugh score1 | 8 (5-14) | 7 (5-14) | 8 (5-13) | < 0.0001 |
Child-Pugh score1 > 8 (n = 87) | 22 | 65 | < 0.0500 | |
Diabetes mellitus | 67 (27.9) | 29 | 38 | < 0.0500 |
Table 2 Allelic and genotypic frequencies of the VDR FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms in controls and liver cirrhosis patients n (%)
VDR | Control subjects (n = 236) | Liver cirrhosis (n = 240) | OR | 95% CI | P1 |
F = 0.646 | F = 0.665 | 1 | Ref. | ||
FokI | f = 0.354 | f = 0.335 | 1.085 | 0.831-1.417 | NS |
B = 0.392 | B = 0.421 | 1 | Ref. | ||
BsmI | b = 0.608 | b = 0.579 | 1.127 | 0.870-1.460 | NS |
A = 0.570 | A = 0.590 | 1 | Ref. | ||
ApaI | a = 0.430 | a = 0.410 | 1.084 | 0.838-1.402 | NS |
T = 0.608 | T = 0.579 | 1 | Ref. | ||
TaqI | t = 0.392 | t = 0.421 | 0.887 | 0.685-1.149 | NS |
F/F = 104 (44.1) | F/F = 105 (43.8) | 1 | Ref. | ||
FokI | F/f = 97 (41.1) | F/f = 109 (45.4) | 1.113 | 0.758-1.635 | NS |
f/f = 35 (14.8) | f/f = 26 (10.8) | 0.736 | 0.416-1.303 | NS | |
B/B = 41 (17.4) | B/B = 40 (16.7) | 1 | Ref. | ||
BsmI | B/b = 103 (43.6) | B/b = 122 (50.8) | 1.214 | 0.732-2.014 | NS |
b/b = 92 (39.0) | b/b = 78 (32.5) | 0.869 | 0.513-1.473 | NS | |
A/A = 76 (32.2) | A/A = 80 (33.3) | 1 | Ref. | ||
ApaI | A/a = 117 (49.6) | A/a = 123 (51.3) | 0.999 | 0.668-1.494 | NS |
a/a = 43 (18.2) | a/a = 37 (15.4) | 0.817 | 0.477-1.400 | NS | |
T/T = 89 (37.7) | T/T = 76 (31.7) | 1 | Ref. | ||
TaqI | T/t = 109 (46.2) | T/t = 126 (52.5) | 1.354 | 0.909-2.017 | NS |
t/t = 38 (16.1) | t/t = 38 (15.8) | 1.171 | 0.681-2.013 | NS |
Table 3 Estimated VDR haplotype frequencies [FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms] in control subjects and in patients with liver cirrhosis of viral and alcoholic origin
Control subjects (n = 236) | Alcoholic cirrhosis (n = 103) | Viral cirrhosis (n = 137) | ||||||
Haplotypes | n | Frequencies | Haplotypes | n | Frequencies | Haplotypes | n | Frequencies |
C-A-T-C | 139 | 0.295 | C-A-T-C | 59 | 0.286 | C-A-T-C | 103 | 0.376 |
T-G-G-T | 102 | 0.216 | T-G-G-T | 46 | 0.223 | T-G-G-T | 56 | 0.204 |
C-G-G-T | 99 | 0.210 | C-G-G-T | 50 | 0.243 | C-G-G-T | 43 | 0.158 |
C-G-T-T | 58 | 0.123 | C-G-T-T | 29 | 0.141 | C-G-T-T | 25 | 0.091 |
T-A-T-C | 41 | 0.087 | T-A-T-C | 11 | 0.053 | T-A-T-C | 23 | 0.084 |
T-G-T-T | 23 | 0.049 | T-G-T-T | 6 | 0.029 | T-G-T-T | 19 | 0.069 |
C-A-T-T | 4 | 0.008 | C-A-T-T | 1 | 0.005 | C-A-T-T | 3 | 0.011 |
C-G-T-C | 3 | 0.006 | C-G-T-C | 2 | 0.010 | C-G-T-C | 2 | 0.007 |
C-G-G-C | 2 | 0.004 | C-A-G-C | 2 | 0.010 | |||
T-A-T-T | 1 | 0.002 |
Table 4 Genotypic frequencies of the VDR FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms in liver cirrhosis patients grouped according to the presence or absence of HCC
VDR | HCC absent (n = 160) | HCC present (n = 80) | OR | 95% CI | P1 |
F/F = 69 (43.1) | F/F = 36 (45.0) | 1 | Ref. | ||
FokI | F/f = 73 (45.6) | F/f = 36 (45.0) | 0.945 | 0.537-1.663 | NS |
f/f = 18 (11.3) | f/f = 8 (10.0) | 0.852 | 0.345-2.113 | NS | |
B/B = 28 (17.5) | B/B = 12 (15.0) | 1 | Ref. | 2 | |
BsmI | B/b = 87 (54.4) | B/b = 35 (43.8) | 0.939 | 0.433-2.028 | NS |
b/b = 45 (28.1) | b/b = 33 (41.2) | 1.711 | 0.766-3.813 | NS | |
A/A = 53 (33.1) | A/A = 27 (33.8) | 1 | Ref. | ||
ApaI | A/a = 85 (53.1) | A/a = 38 (47.5) | 0.878 | 0.483-1.595 | NS |
a/a = 22 (13.8) | a/a = 15 (18.7) | 1.338 | 0.605-2.968 | NS | |
T/T = 44 (27.5) | T/T = 32 (40.0) | 1 | Ref. | 3 | |
TaqI | T/t = 88 (55.0) | T/t = 38 (47.5) | 0.594 | 0.329-1.072 | 0.08 |
t/t = 28 (17.5) | t/t = 10 (12.5) | 0.491 | 0.212-1.141 | 0.09 |
Table 5 Estimated VDR haplotype frequencies [FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms] in patients with liver cirrhosis of viral and alcoholic origin according to the presence of HCC
Alcoholic cirrhosis (n = 103) | Viral cirrhosis (n = 137) | ||||||||||
HCC present (n = 30) | HCC absent (n = 73) | HCC present (n = 50) | HCC absent (n = 87) | ||||||||
Haplotypes | n | Frequencies | Haplotypes | n | Frequencies | Haplotypes | n | Frequencies | Haplotypes | n | Frequencies |
C-A-T-C | 9 | 0.150 | C-A-T-C | 50 | 0.343 | C-A-T-C | 40 | 0.40 | C-A-T-C | 64 | 0.368 |
T-G-G-T | 16 | 0.267 | T-G-G-T | 30 | 0.205 | T-G-G-T | 15 | 0.15 | T-G-G-T | 38 | 0.218 |
C-G-G-T | 18 | 0.300 | C-G-G-T | 32 | 0.219 | C-G-G-T | 19 | 0.19 | C-G-G-T | 27 | 0.155 |
C-G-T-T | 14 | 0.233 | C-G-T-T | 15 | 0.103 | C-G-T-T | 5 | 0.05 | C-G-T-T | 17 | 0.098 |
T-A-T-C | 1 | 0.017 | T-A-T-C | 10 | 0.068 | T-A-T-C | 7 | 0.07 | T-A-T-C | 15 | 0.086 |
T-G-T-T | 2 | 0.033 | T-G-T-T | 4 | 0.027 | T-G-T-T | 11 | 0.11 | T-G-T-T | 11 | 0.063 |
C-A-T-T | 1 | 0.007 | C-A-T-T | 2 | 0.02 | C-G-T-C | 1 | 0.006 | |||
C-G-T-C | 2 | 0.014 | C-G-T-C | 1 | 0.01 | T-A-T-T | 1 | 0.006 | |||
C-G-G-C | 2 | 0.014 |
- Citation: Falleti E, Bitetto D, Fabris C, Cussigh A, Fontanini E, Fornasiere E, Fumolo E, Bignulin S, Cmet S, Minisini R, Pirisi M, Toniutto P. Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis. World J Gastroenterol 2010; 16(24): 3016-3024
- URL: https://www.wjgnet.com/1007-9327/full/v16/i24/3016.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i24.3016