Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis

Table 1 Patient characteristics

	AIH	ALD	Hepatitis B	Hepatitis C	Other
n	11	30	9	13	9
Sex (M/F)	3/8	21/9	7/2	8/5	5/4
Age (yr, ± SE)	47.4 ± 7	52.9 ± 8	52.5 ± 5	50.5 ± 8	51.8 ± 9
Child A	6	11	7	6	4
Child B	3	17	2	6	4
Child C	2	4	0	1	1

AIH: Autoimmune hepatitis (including primary biliary sclerosis and primary sclerosing cholangitis; ALD: Alcoholic liver disease. Other includes patients with polycystic liver and with non-specified cirrhosis.

Table 2 Types and frequencies of circulating progenitor cells in patients with liver cirrhosis

Cell subset	Positive/total number of patients	% of the MNCs
CD133+	44/72 (61.2%)	5.8 ± 4.9
c-kit+	65/72 (90.9%)	9.2 ± 3.2
Bcrp-1+	12/72 (17.9%)	4.1 ± 3.7

Table 3 Clonogenic potential of circulating hematopoietic progenitor cell populations (mean ± SE)

Cells	BFU-E	CFU-E	CFU-GEMM	CFU-GM	CFU-G	CFU-M
c-kit	5 ± 2	13 ± 5	3 ± 3	19 ± 8	53 ± 11	27 ± 9
Bcrp-1	8 ± 3	9 ± 2	4 ± 1	9 ± 7	37 ± 14	13 ± 5
CD133	0	0	0	5 ± 3	46 ± 13	63 ± 15

The results of three independent experiments per populations are shown, each experiment was performed in duplicate. BFU-E: Burst-forming unit erythrocyte; CFU-E: Colony-forming unit erythrocyte; CFU-GEMM: Colony-forming unit granulocyte-erythrocyte-macrophage-megakaryocyte; CFU-GM: Colony-forming unit granulocyte-macrophage; CFU-G: Colony-forming unit granulocyte; CFU-M: Colony-forming unit macrophage.