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World J Gastroenterol. Apr 14, 2010; 16(14): 1788-1794
Published online Apr 14, 2010. doi: 10.3748/wjg.v16.i14.1788
Published online Apr 14, 2010. doi: 10.3748/wjg.v16.i14.1788
Table 1 Parameters of patients with or without progression n (%)
No progression group (n = 137) | Group I (n = 134) | P value | Group II (n = 101) | P value | |
Age (yr) | |||||
≤ 40 | 32 (23.4) | 45 (33.6)a | 0.045 | 35 (34.7)b | 0.027 |
40-50 | 76 (55.5) | 60 (44.8) | 42 (41.6) | ||
≥ 50 | 29 (21.1) | 29 (21.6) | 0.330 | 24 (23.7) | 0.200 |
mean ± SD | 44.2 ± 0.7 | 43.8 ± 0.6 | 46.7 ± 0.7 | ||
Sex | 0.600 | 0.260 | |||
Male | 59 (43.1) | 62 (45.9) | 51 (50.5) | ||
Female | 78 (56.9) | 72 (54.1) | 50 (49.5) | ||
H. pylori infection | < 0.001 | 0.100 | |||
Negative | 59 (43.1) | 30 (22.4) | 33 (32.7) | ||
Positive | 78 (56.9) | 104 (77.6)c | 68 (67.3) |
Table 2 Cytokine genotype frequencies in patients with or without progression n (%)
No progression group (n = 137) | Group I (n = 134) | Group II (n = 101) | |
IL-8-251 | |||
TT | 59 (43.1) | 39 (29.1) | 25 (24.8) |
TA | 64 (46.7) | 70 (52.2) | 65 (64.4) |
AA | 14 (10.2) | 25 (18.7) | 11 (10.9) |
MIF-173 | |||
GG | 100 (73.0) | 71 (53.0) | 62 (60.4) |
GC | 34 (24.8) | 54 (40.3) | 29 (28.7) |
CC | 3 (2.2) | 9 (6.7) | 10 (10.9) |
Table 3 Relation between cytokine gene polymorphisms and development of precursory lesions of GC n (%)
Genotype | Group I (n = 134) OR (95% CI) | Group II (n = 101) OR (95% CI) |
IL-8-251 | ||
TT | 1.00 | 1.00 |
TA | 1.64 (0.96-2.79) | 2.27 (1.25-4.14) |
AA | 2.62 (1.23-5.72) | 1.20 (0.76-1.90) |
TA + AA | 1.81 (1.06-3.09) | 2.07 (1.16-3.69) |
MIF-173 | ||
GG | 1.00 | 1.00 |
GC | 2.36 (1.38-4.02) | 1.50 (0.57-3.94) |
CC | 1.92 (0.95-3.87) | 2.27 (1.16-4.46) |
GC + CC | 2.07 (1.21-3.55) | 3.84 (1.58-9.34) |
Table 4 Risk of SCAG in patients with IL-8-251 and MIF-173 genotypes and H. pylori infection
Table 5 Relation between risk of IM and MIF-173 genotypes infection
- Citation: Li ZW, Wu Y, Sun Y, Liu LY, Tian MM, Feng GS, You WC, Li JY. Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia. World J Gastroenterol 2010; 16(14): 1788-1794
- URL: https://www.wjgnet.com/1007-9327/full/v16/i14/1788.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i14.1788