Hepatic osteodystrophy and liver cirrhosis

Table 1 Clinical features and laboratory test results of the liver cirrhosis and control groups

	Cirrhosis (n = 55)	Control (n = 30)	P-value
Lumbar total T-score (g/cm2)	-1.6 ± 1.2	-0.25 ± 1.3	< 0.001
Lumbar total Z-score (g/cm2)	-1.2 ± 1.2	-0.6 ± 1.3	< 0.001
Total femur T-score (g/cm2)	-0.05 ± 1	0.6 ± 0.9	0.003
Total femur Z-score (g/cm2)	-0.08 ± 1.5	0.7 ± 0.9	0.003
Age (yr)	44.8 ± 12.9	34.8 ± 8.2	< 0.001
BMI (kg/m2)	25.5 ± 4.3	25.5 ± 3.7	0.970
IL-1 pg/mL	3.4 ± 8.8	1.6 ± 3.5	0.290
IL-6 pg/mL	27.9 ± 51.6	3.3 ± 3.1	0.010
TNF-α pg/mL	42.6 ± 33.2	25.3 ± 12.3	0.007
AFP (ng/mL)	2.6 ± 16.9	2.6 ± 1.1	0.100
Direct biluribin (mg/dL)	0.3 ± 0.2	0.9 ± 0.7	< 0.001
CRP (mg/L)	5.8 ± 5.9	5.4 ± 11.3	0.800
Osteocalcin (ng/mL)	1.05 ± 2.5	7.0 ± 13	0.002
IGF-1 (ng/mL)	47.7 ± 26.2	143.4 ± 53.2	< 0.001
ALP (IU/L)	109.2 ± 57	62.6 ± 32.5	< 0.001
24 h urinary Ca2+ (mg/dL)	169.6 ± 227.2	287 ± 168.6	0.003
Deoxypyridinoline/creatinine (pmol/μmol)	9.4 ± 9.9	8.1 ± 5.3	0.510
pyridinoline/creatinine (pmol/μmol)	51.3 ± 66.6	29 ± 25.8	0.080
Cortisol level μg/dL	11.1 ± 4.8	12.6 ± 4.3	0.150
PTH level μg/dL	42.7 ± 38	34.8 ± 10.9	0.270
Vit D3 level μg/L	18.6 ± 13.3	18.4 ± 8.9	0.950
Albumin (g/dL)	2.5 ± 0.5	4 ± 0.4	0.001
Prothrombin time (s)	17.1 ± 5.2	11.7 ± 1.7	< 0.001
Sedimentation rate (h)	18.8 ± 10.6	11.6 ± 9.6	0.030

BMI: Body mass index; IL: Interleukin; TNF: Tumor necrosis factor; AFP: α-fetoprotein; CRP: C-reactive protein; ALP: Alkaline phosphatase; IGF: Insulin-like growth factor.