Combined MELD and blood lipid level in evaluating the prognosis of decompensated cirrhosis

Table 1 Clinical features of 198 cirrhotic patients at 3-mo and 1-yr follow-ups (mean ± SD)

Clinical features	Follow-up at 3 mo			Follow-up at 1 yr
	Survival group	Death group	P value	Survival group	Death group	P value
MELD	13.6 ± 6.40	23.3 ± 9.82	0.000a	12.42 ± 5.29	22.90 ± 8.90	0.000a
TG (mmol/L)	0.86 ± 0.36	0.80 ± 0.29	0.036a	0.94 ± 0.39	0.76 ± 0.26	0.003a
TC (mmol/L)	3.22 ± 1.07	2.63 ± 1.04	0.006a	3.36 ± 1.11	2.77 ± 1.00	0.001a
HDL (mmol/L)	1.30 ± 0.60	0.93 ± 0.46	0.013a	1.37 ± 0.50	1.06 ± 0.62	0.021a
LDL (mmol/L)	1.88 ± 0.71	1.67 ± 0.77	0.010a	2.04 ± 0.74	1.66 ± 0.69	0.020a

^aP < 0.05, the death group vs the survival group. MELD: Model for end-stage liver disease; TG: Triglyeride; TC: Cholesterol; HDL: High density lipoproteins; LDL: Low density lipoprotein.

Table 2 Relationship between lipid levels and MELD score in 198 patients with cirrhosis (mean ± SD)

	Group 1 (MELD < 11)	Group 2 (11 ≤MELD < 21)	P value (groups 1 and 2)	Group 3 (MELD≥21)	P value (groups 2 and 3)
TG (mmol/L)	1.01 ± 0.46	0.96 ± 0.33	0.089	0.80 ± 0.31	0.021b
TC (mmol/L)	3.68 ± 1.23	3.03 ± 0.91	0.006d	2.62 ± 1.18	0.002d
HDL (mmol/L)	1.97 ± 0.73	1.34 ± 0.83	0.026d	0.76 ± 0.55	0.018d
LDL (mmol/L)	1.89 ± 0.44	1.71 ± 0.44	0.092	1.42 ± 0.86	0.032b

^bP < 0.05, group 2 vs group 3;

^dP < 0.05, group 1 vs group 2 and group 2 vs group 3.

Table 3 Multivariate Cox regression of 198 patients with decompensated cirrhosis

	HR	95% CI	P
MELD ≥ 21	2.69	1.58-4.58	< 0.001
TC ≤ 2.8 mmol/L	0.68	0.31-1.43	0.020

HR: Hazard ratios.