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Copyright ©2010 Baishideng.
World J Gastroenterol. Mar 21, 2010; 16(11): 1358-1365
Published online Mar 21, 2010. doi: 10.3748/wjg.v16.i11.1358
Table 1 Ethanol-induced changes in cytoskeleton-associated protein gene expression
Gene productExpression levelsSystemEtOH exposureRef.
α1-tubulinIncreasedRat liverChronic (IG)[1]
β5-tubulinIncreasedRat liverChronic (IG)[1]
β-tubulinDecreasedRat liverChronic[2]
Kinesin 2cIncreasedMouse liverAcute[3]
TauDecreasedRat liverChronic[2]
αE integrinIncreasedRat liverChronic (IG)[4]
PDZ and LIM domain protein 1DecreasedRat liverChronic[5]
Thymosin β-like proteinDecreasedRat liverChronic[2]
Myosin 1bDecreasedHepG2 (+ CYP2E1)Acute[4]
Myosin 1EDecreasedRat liverChronic[2]
Myosin light chain 2DecreasedRat liverChronic[2]
Myosin light chain 3DecreasedRat liverChronic[2]
TitinDecreasedHepG2 (+ CYP2E1)Acute[4]
Myosin VII A and Rab interacting protein 1IncreasedRat liverChronic (IG)[6]
ZO-2DecreasedRat liverChronic[5]
Cadherin 17IncreasedRat liverChronic (IG)[4]
Table 2 Ethanol-induced changes in cytoskeletal protein expression levels
ProteinExpression levelsSystemEtOH exposureRef.
α-tubulinNo changeWIF-B cells, rat liver, isolated hepatocytesChronic[7,8]
α-tubulinDecreasedRat liverChronic[9]
DyneinNo changeRat liverChronic[7]
KinesinNo changeRat liverChronic[7]
ActinNo changeWIF-B cells, rat liverChronic[10,11]
CortactinNo changeWIF-B cells, Rat liverChronic[11]
VinculinNo changeRat liverChronic[10]
FAKNo changeRat liverChronic[10]
PaxillinNo changeRat liverChronic[10]
RhoANo changeRat liverChronic[12]
RacIncreasedRat liverChronic[12]
Cdc42IncreasedRat liverChronic[12]
α1 integrinIncreasedRat liverChronic[10,13]
α5 integrinIncreasedRat liverChronic[10,13]
β1 integrinIncreasedRat liverChronic[10,13]
Keratin 81No changeRat liverChronic[14]
Keratin 181No changeRat liverChronic[14]
Table 3 Ethanol-induced cytoskeletal protein modifications
ModificationProteinSystemEtOH exposureRef.
Lysine acetylationα-tubulinWIF-B cells, rat liverChronic[8]
β-actinRat liverChronic[11]
CortactinRat liverChronic[11]
DephosphorylationKeratin 81Rat liverChronic[15]
Keratin 181Rat liverChronic[15]
PhosphorylationKeratin 8Rat liverAcute[16]
Keratin 18Rat liverAcute[16]
Cysteine oxidation50 kDa dynactin subunitMouse liverChronic[17]
α-actinMouse liverChronic[17]
β-actinMouse liverChronic[17]
Keratin 1Mouse liverChronic[17]
Keratin 2Mouse liverChronic[17]
Keratin 9Mouse liverChronic[17]
Keratin 10Mouse liverChronic[17]
Keratin 14Mouse liverChronic[17]
Keratin 16Mouse liverChronic[17]
Lysine adduction by acetaldehydeα-tubulinIn vitro2N/A[18-20]
MAPSIn vitro4N/A[18]
ActinIn vitro5N/A[21]