Is there an association between Helicobacter pylori in the inlet patch and globus sensation?

Table 1 Characteristics of the subjects

	HGM (+)	HGM (-)
n	68	6692
Sex
Female (%)	36 (53.1)	3173 (47.4)
Male (%)	32 (46.9)	3519 (52.6)
Female/male	1.12	0.88
Age range (yr)	(17-56)	(16-90)
Mean age (± SE)	37.29 ± 1.85a	47.5 ± 0.3
Endoscopic Barrett’s esophagus	9 (13.2)a	166 (2.4)
Erosive esophagitis	7 (10.3)	636 (9.5)
Globus (%)	48 (70.6)a	0
Dyspepsia(%)	60 (88.2)	6550 (97.8)

HGM: Heterotopic gastric mucosa.

^aP < 0.05.

Table 2 Clinicopathologic classification and characteristics of CHGM patches

Clinicopathologic	Number (%)	Symptoms/findings
HGM I	12 (17.6)	Asymptomatic
HGM II	53 (77.9)	48 GS, 4 cough, 1 hoarseness
HGM III	2 (2. 9)	1 ulcus , 1 polyp
HGM IV	0
HGM V	1 (1.4)	Esophageal adenocarcinoma

CHGM: Cervical heterotopic gastric mucosa; GS: Globus sensation; Cough: Together with clearing of the throat.

Table 3 Histological characteristics of heterotopic gastric mucosal patches

Histological characteristics	n
Type of patch
Fundic	44
Antral	15
Foveolar epithelium	8
Complete IM	1
Chronic inflammation	68
IM (+), Hp (-)	6 (3 antral-type, 2 fundic-type, 1 complete IM)
IM (-), Hp (+)	15 (3 antral-type, 12 fundic-type)
IM (+), Hp (+)	1 (1 fundic-type)
IM (-), Hp (-)	46 (9 antral-type, 29 fundic-type, 8 foveolar epithelium)

IM: Intestinal metaplasia; Hp: Helicobacter pylori.

Table 4 Comparison of the HP (+) and Hp (-) subjects with CHGM

	Hp (+) CHGM (n = 16)	Hp (-) CHGM (n = 52)
Globus, n (%)	16 (100)	32 (61.5)a
Age (yr)	35.6 ± 2.3	38.6 ± 2.5
Female n (%)	11 (68.8)a	25 (48.1)
Male n (%)	5 (31.2)	27 (51.9)a
Fundic-type	13 (81.2)	31 (59.6)a
Antral-type	3 (18.8)	12 (23.1)
Intestinal metaplasia	-	1 (1.9)
Foveolar epithelium	-	8 (15.4)

^aP < 0.05.