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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Dec 21, 2009; 15(47): 5976-5982
Published online Dec 21, 2009. doi: 10.3748/wjg.15.5976
Published online Dec 21, 2009. doi: 10.3748/wjg.15.5976
Table 1 Clinicopathological characteristics of 429 ICC patients
No. of cases | Total No. of cases | Percentage (%) | |
Gender | 429 | ||
Male | 301 | 70.2 | |
Female | 128 | 29.8 | |
Age (yr) | 429 | ||
< 53 | 220 | 51.3 | |
≥ 53 | 209 | 48.7 | |
Choledocholithiasis | 429 | ||
No | 383 | 89.3 | |
Yes | 46 | 10.7 | |
Pathology T | 429 | ||
T1 | 11 | 2.5 | |
T2 | 159 | 37.1 | |
T3 | 112 | 26.1 | |
T4 | 147 | 34.3 | |
Pathology N | 429 | ||
N0 | 341 | 79.5 | |
N1 | 88 | 20.5 | |
Pathology M | 429 | ||
M0 | 408 | 95.1 | |
M1 | 21 | 4.9 | |
Pathology stage | 429 | ||
I | 11 | 2.5 | |
II | 126 | 29.4 | |
III | 133 | 31.0 | |
IV | 159 | 37.1 | |
Maximum tumor diameter (cm) | 429 | ||
≤ 5 | 145 | 33.8 | |
> 5, ≤ 10 | 186 | 43.4 | |
> 10 | 76 | 17.7 | |
Diffuse type | 22 | 5.1 | |
Macroscopic satellite lesions | 429 | ||
No | 330 | 76.9 | |
≤ 3 | 40 | 9.3 | |
> 3 | 59 | 13.8 | |
Macroscopic tumor thrombi | 429 | ||
No | 382 | 89.0 | |
In blood vessel | 32 | 7.5 | |
In bile duct | 10 | 2.3 | |
In both | 5 | 1.2 | |
Serum HBsAg and HBcAb | 427 | ||
HBsAg (+) | 198 | 46.4 | |
HBsAg (-) and HBcAb (+) | 60 | 14.0 | |
HBsAg (-) and HBcAb (-) | 169 | 39.6 | |
Serum AFP ( μg/L) | 422 | ||
No | 332 | 78.7 | |
> 20, ≤ 1000 | 70 | 16.6 | |
> 1000 | 20 | 4.7 | |
Serum CEA ( μg/L) | 420 | ||
No | 370 | 88.1 | |
> 10, ≤ 100 | 36 | 8.6 | |
> 100 | 14 | 3.3 | |
Serum CA19-9 (U/mL) | 421 | ||
No | 179 | 42.5 | |
> 37, ≤ 507 | 143 | 34.0 | |
> 507 | 99 | 23.5 |
Table 2 Surgery selection and prognosis
Table 3 Multivariate analysis of patient survival
Regression coefficient | Standard error | P value | Relative risk | 95% CI | |
Curative resection | 0.658 | 0.173 | 0.000 | 1.931 | 1.375-2.713 |
Lymph node metastases | 0.432 | 0.218 | 0.048 | 1.540 | 1.004-2.361 |
Macroscopic tumor thrombi | 0.455 | 0.206 | 0.027 | 1.576 | 1.053-2.360 |
Tumor size | 0.159 | 0.080 | 0.046 | 1.173 | 1.003-1.372 |
CA19-9 | 0.191 | 0.085 | 0.024 | 1.210 | 1.025-1.428 |
Table 4 Association of CA19-9 with clinicopathological parameters of the patients
CA19-9 expression | |||
> 37 U/mL | ≤37 U/mL | P value | |
Gender | 0.032 | ||
Male | 159 | 135 | |
Female | 83 | 44 | |
Age (yr) | 0.040 | ||
< 53 | 112 | 101 | |
≥ 53 | 130 | 78 | |
Surgical procedures | 0.106 | ||
R0 | 174 | 139 | |
R1 | 44 | 32 | |
Exploratory laparotomy | 24 | 8 | |
Lymph node metastasis | 0.082 | ||
Yes | 182 | 148 | |
No | 57 | 30 | |
Macroscopic satellite lesions | 0.229 | ||
No | 184 | 140 | |
≤ 3 | 20 | 20 | |
> 3 | 38 | 19 | |
Extrahepatic metastases | 0.185 | ||
Yes | 227 | 179 | |
No | 15 | 6 | |
Macroscopic tumor thrombi | 0.440 | ||
Yes | 218 | 157 | |
No | 24 | 22 | |
Microscopic tumor thrombi | 0.192 | ||
Yes | 142 | 120 | |
No | 83 | 53 | |
Tumor differentiation | 0.221 | ||
Well | 4 | 1 | |
Moderate | 85 | 52 | |
Poorly | 126 | 105 | |
Number of lesions | 0.843 | ||
Single | 160 | 120 | |
Multiple | 82 | 59 | |
Tumor size (cm) | 0.002 | ||
≤ 5 | 69 | 72 | |
> 5, ≤ 10 | 120 | 64 | |
> 10 | 37 | 39 | |
Diffuse type | 16 | 4 | |
HBsAg | 0.049 | ||
Yes | 101 | 92 | |
No | 141 | 87 | |
Cirrhosis | 0.000 | ||
Yes | 68 | 80 | |
No | 174 | 99 |
Table 5 Logistic regression analysis in relationship between CA19-9 expression, lymph node metastases, and liver cirrhosis
Regression coefficient | Standard error | P value | Relative risk | 95% CI | |
Lymph node metastases | 0.637 | 0.295 | 0.031 | 1.891 | 1.060-3.374 |
Cirrhosis | -0.539 | 0.230 | 0.019 | 0.584 | 0.372-0.915 |
Constant | 0.336 | 0.146 | 0.021 | 1.340 |
Table 6 Comparison of post-operative survival after R0 resection
Author | No. of total | No. of R0 | Ratio (%) | Survival (%) | ||
1-yr | 3-yr | 5-yr | ||||
Ohtsuka et al[22], 2003 | 50 | 34 | 68 | 61.6 | 37.6 | 22.5 |
Morimoto et al[23], 20031 | 51 | 35 | 68.6 | 68.2 | 44.1 | 32.4 |
Nakagawa et al[24], 2005 | 53 | 44 | 83.0 | 66.2 | 38.3 | 26.3 |
Lang et al[25], 2006 | 54 | 30 | 55.5 | 83 | 58 | 48 |
DeOliveira et al[26], 2007 | 44 | 34 | 77.3 | NR | NR | 63 |
Konstadoulakis et al[27], 2008 | 72 | 54 | 75 | 80 | 49 | 25 |
Our current study | 429 | 319 | 74.3 | 62.5 | 30.2 | 23.6 |
- Citation: Shen WF, Zhong W, Xu F, Kan T, Geng L, Xie F, Sui CJ, Yang JM. Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma. World J Gastroenterol 2009; 15(47): 5976-5982
- URL: https://www.wjgnet.com/1007-9327/full/v15/i47/5976.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.5976