Brief Article
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Dec 21, 2009; 15(47): 5946-5952
Published online Dec 21, 2009. doi: 10.3748/wjg.15.5946
Table 1 Baseline characteristics of enrolled patients (mean ± SD)
PR group (n = 15)PK group (n = 16)PRK group (n = 14)P-value
Age (yr)45 ± 1248 ± 1242 ± 10NS
Sex (M/F)9/69/79/5NS
HCV-RNA × 103 IU/mL429 ± 5781261 ± 10731555 ± 13220.01
HCV-RNA > 700 × 103 IU/mL (%)4 (27)8 (50)10 (71)0.02
ALT (U/L)82 ± 4585 ± 3387 ± 49NS
Median total HAI1 (range)8 (3-14)10 (6-13)8 (3-10)NS
Median grading (range)7 (2-11)9 (5-10)7 (3-9)NS
Median fibrosis (range)1 (1-3)1 (1-3)1 (0-3)NS
Table 2 Virological response rates by study group n (%)
PR group (n = 15)PK group (n = 16)PRK group (n = 14)P-value
Virological response rate
Week 1001 (7.1)NS
Week 21 (6.7)1 (6.3)2 (14.3)NS
Week 45 (33.3)2 (12.5)3 (21.4)NS
Week 1210 (66.7)7 (43.8)7 (50)NS
Week 2411 (73.3)11 (68.8)10 (71.4)NS
ETR11 (73.3)11 (68.8)10 (71.4)NS
Relapse rate4/11 (36.4)6/11 (54.5)2/10 (20)NS
SVR7 (46.7)5 (31.3)8 (57.1)NS
Table 3 Baseline characteristics of the patients enrolled in the molecular study (mean ± SD) n (%)
PR group (n = 9)PK group (n = 9)PRK group (n = 9)P-value
Age (yr)42 ± 1354 ± 942 ± 120.04
Sex (M/F)5/44/55/4NS
HCV-RNA × 103 IU/mL263 ± 2321032 ± 8781742 ± 13920.01
HCV-RNA > 700 × 103 IU/mL1 (27)4 (44)7 (78)0.02
ALT (U/L)70 ± 2180 ± 27100 ± 57NS
ETR7 (78)5 (56)6 (67)NS
SVR5 (56)3 (33)5 (56)NS
Table 4 Side effects occurring during 48 wk of treatment n (%)
PR group (n = 15)PK group (n = 16)PRK group (n = 14)P-value
Anemia8 (53)7 (44)11 (79)NS
Neutropenia9 (60)7 (44)10 (71)NS
Arthro-myalgia4 (27)4 (25)5 (36)NS
Headache3 (20)3 (19)2 (14)NS
Fatigue5 (33)5 (31)4 (29)NS
Flu-like symptoms4 (27)4 (25)2 (14)NS
Psychiatric disorders5 (33)4 (25)4 (29)NS
Gastrointestinal disorders6 (40)3 (19)4 (29)NS
Pruritus4 (27)1 (6)0NS
Insomnia2 (13)2 (12.5)2 (14)NS
Table 5 Time course evaluation of hemoglobin and creatinine serum levels during treatment (mean ± SD)
PR group (n = 15)PK group (n = 16)PRK group (n = 14)
Hemoglobin (g/dL)
Baseline14.5 ± 1.314.2 ± 1.914.9 ± 1.5
Week 1212.2 ± 1.412.5 ± 1.712.2 ± 1.6
Week 2412.2 ± 1.612.6 ± 1.811.9 ± 1.7
Week 4811.6 ± 1.413.1 ± 1.812.0 ± 1.6
Creatinine (mg/dL)
Baseline0.97 ± 0.130.82 ± 0.221.01 ± 0.07
Week 120.87 ± 0.110.82 ± 0.160.92 ± 0.12
Week 240.86 ± 0.150.79 ± 0.160.91 ± 0.15
Week 480.44 ± 0.150.80 ± 0.170.92 ± 0.15