COX-2 polymorphisms -765G→C and -1195A→G and colorectal cancer risk

Table 1 Characteristics of patients with colorectal cancer (CRC) and controls (mean ± SD)

	Patients with CRC (n = 326)	Controls (n = 369)
Age (yr)	62.7 ± 11.7	64.5 ± 10.7
Male gender	195 (59.8%)	218 (59.1%)
Female gender	131 (40.2%)	151 (40.9%)
Localization of tumor1
Proximal2	101 (31.0%)
Distal3	222 (68.1%)

¹Note that the localization of the tumor was unknown in 3 patients;

²Proximal tumor: cecum, ascending and transverse colon;

³Distal tumor: descending colon, sigmoid, rectosigmoid junction and rectum.

Table 2 Genotype distribution and OR of the COX-2 -1195A→G and -765G→C polymorphisms in patients with CRC and controls

Genotype	Patients with CRC (n = 326)	Controls (n = 369)	OR (95% CI)
-1195AA	213 (65.3%)	232 (62.9%)	Reference
-1195GA	101 (31.0%)	124 (33.6%)	0.90 (0.66-1.23)
-1195GG	12 (3.7%)	13 (3.5%)	1.01 (0.45-2.25)
-765GG	241 (73.9%)	249 (67.5%)	Reference
-765GC	75 (23.0%)	112 (30.4%)	0.69 (0.49-0.97)
-765CC	10 (3.1%)	8 (2.2%)	1.29 (0.50-3.33)

OR: Odds ratio; CI: Confidence interval.

Table 3 COX-2 haplotypes in patients with CRC and controls

Haplotype	Patients with CRC (n = 326)	Controls (n = 369)	OR (95% CI)
AC/AC	9 (2.8%)	8 (2.2%)	1.16 (0.40-3.42)
AG/AC	59 (18.1%)	74 (20.1%)	0.83 (0.54-1.27)
AG/AG	145 (44.5%)	150 (40.7%)	Reference
GC/AC	1 (0.3%)	-	-
GG/AC	16 (4.9%)	38 (10.3%)	0.44 (0.22-0.85)
GG/AG	84 (25.8%)	86 (23.3%)	1.01 (0.68-1.50)
GG/GG	12 (3.7%)	13 (3.5%)	0.92 (0.38-2.24)