Early graft dysfunction following adult-to-adult living-related liver transplantation: Predictive factors and outcomes

Table 1 Univariate analysis of epidemiologic data in the group with EGD vs the group without EGD, median (range)

	With EGD (10 pts)	Without EGD (63 pts)	P value
Age recipient	52.72 (38-61)	57.6 (18-68)	NS
Age donors	29.5 (26-54)	30 (18-53)	NS
Sex recipient (M/F)	5/5	38/25	NS
Sex donors (M/F)	5/5	39/24	NS

EGD: Early graft dysfunction.

Table 2 Univariate analysis of pre-transplant clinical data in the two groups: EGD vs non-EGD

	EGD (10 pts)	Non-EGD (63 pts)	P value
Pre-transplant serum bilirubin (mg/dL)	8.71 (1.27-29.21)	2.01 (0.28-24.82)	0.013
1Pre-transplant serum albumin (g/dL)	2.6 (2.2-3.3)	2.8 (1.31-4)	NS
Pre-transplant serum sodium (mEq/L)	133 (122-145)	138 (126-144)	NS
Pre-transplant INR	1.38 (1.27-2.55)	1.22 (0.81-2.55)	0.001
Pre-transplant platelets (mmc)	48 000 (22 000-60 000)	71 000 (24-400)	0.007
Pre-transplant WBC (mmc)	4575 (1700-7200)	4200 (1500-15 500)	NS
Child-Pugh score, points	10.00 (8-12)	8.0 (5-12)	NS
MELD score	20.50 (12-40)	15.0 (6-28)	NS
Meld-Na score	24.25 ± 7.9	18.13 ± 5.8	0.004
Steatosis (No/Macro 1%-2%/Macro 10%-20%/Macro 25%-30%)	(6/2/2/0)	(35/15/9/4)	NS
Liver volume (mL)	780 (590-1186)	1016 (557-1482)	NS
Spleen volume (mL)	983 (648-1382)	709 (161-2711)	NS
S/LVR	0.96 (0.55-2.34)	0.78 (0.13-2.95)	NS
GRDWR	1.26 (0.79-1.59)	1.48 (0.81-2.96)	NS
GS/SLV	59.52 (37.34-70.19)	68.5 (38.7-132.6)	NS

¹Neither group of patients received albumin supplementation before transplant. S/LVR: Spleen/liver volume ratio; GRDWR: Graft-to-recipient body weight ratio; GS/SLV: Graft-to-recipient standard liver volume. Data are expressed as mean (range), or mean ± SD.

Table 3 Univariate analysis of intraoperative parameters in the two groups: EGD vs non-EGD

	EGD (10 pts)	Non-EGD (63 pts)	P value
MAP, mmHg	73.8 ± 13	76.7 ± 12	NS
SVR dyn·s·cm-5	676 (350-1429)	704 (308-1249)	NS
C/O, L/min	6.9 (3.7-12)	9.4 (6-11.8)	NS
C/I, L/min per meter2	4.5 (3.6-7.5)	4.2 (2.2-6.4)	NS
PRBC	12 (0-47)	3 (0-34)	NS
Units plasma transfused	14 (0-47)	4 (0-34)	0.036

MAP: Mean arterial pressure; SVR: Systemic vascular resistance; C/O: Cardiac output; C/I: Cardiac index; PRBC: Units of transfused packed red blood cells. Data are expressed as mean (range), or mean ± SD.

Table 4 Multivariate analysis of pre-transplant epidemiologic and clinical data in the two groups: EGD vs non-EGD (logistic regression, backward stepwise procedure)

	P value	OR	95% CI per OR
Meld-Na score	0.025	1.175	1.021; 1.352
Pre-transplant platelets, mmc	0.043	0.956	0.915; 0.999