Attenuation of portal hypertension by natural taurine in rats with liver cirrhosis

Table 1 Comparison of the portal hemodynamics in different groups of animals

	MAP (mmHg)	PVP (mmHg)	PVF (mL/min per kg)	SVR (mmHg/mL per min/kg)	PVR (mmHg/mL per min/kg)
NML	105.12 ± 8.56	5.26 ± 0.72	43.15 ± 1.23	2.1 ± 0.23	0.07 ± 0.03
LC - NTau	90.23 ± 4.51a	7.85 ± 0.91a	59.65 ± 4.32a	1.61 ± 0.26b	0.10 ± 0.04a
LC + NTau	93.42 ± 3.25c	5.38 ± 0.65d	48.21 ± 2.25c	1.81 ± 0.35c	0.07 ± 0.05c

^aP < 0.05,

^bP < 0.01 vs the normal healthy control group;

^cP < 0.05,

^dP < 0.01 vs the non-treatment model group.

Table 2 Effects of NTau on the concentrations of NO, cGMP and activity of NOS in portal venous blood

	n	NO (μmol/L)	cGMP (nmol/L)	NOS (U/L)
NML	20	21.41 ± 2.32	0.21 ± 0.02	2.88 ± 1.35
LC - NTau	20	48.56 ± 3.61a	0.34 ± 0.04a	6.45 ± 0.42a
LC + NTau	20	33.14 ± 5.33b	0.26 ± 0.01c	3.81 ± 1.21c

^aP < 0.05 vs the control group;

^bP < 0.01,

^cP < 0.05 vs the non-treated model group.

Table 3 Degrees of liver cirrhosis of rats in different experimental groups

	n	Grading of LC1
		S0	SI	SII	SIII	SIV	SV	SVI
NML	20	0	0	0	0	0	0	0
LC - NTaub	20	0	0	0	0	5	12	3
LC + NTaud	20	0	0	2	6	7	5	0

¹ Grading criteria: S0, normal structure of liver tissue, which is characterized by an absence of deposition of abnormal collagen fibers; S_I, occurrence of fibrous septa (FS) due to hyperplasia of collagen fibers in portal areas (P) or areas surrounding the central vein (C); extension of FS within 50% of the distance between two portal areas (P-P) or between portal and central vein areas (P-C); S_II, extension of fibrous septa beyond 50% of the P-P or P-C; connection of fibrous septa is either incomplete or complete; absence of completely enclosed or separated hepatic lobules; S_III, presence of completely enclosed hepatic lobules by FS; S_IV, separation of hepatic lobules by extensive hyperplasia of collagen fibers; destruction of the normal lobular structure; pseudo-lobules formed are mainly large-square-shaped (> 50%); S_V, concomitant presence of large-square- and small-round-shaped pseudo-lobules (both less than 50%); and S_VI, intrahepatic pseudo-lobules are mainly small-round-shaped (> 50%).

^bP < 0.01 vs the normal healthy control;

^dP < 0.01 vs the non-treated LC group.