Effects of Chai-Qin-Cheng-Qi Decoction on cefotaxime in rats with acute necrotizing pancreatitis

Table 1 Pathological grading and scoring criteria for pancreatic tissue of rats with ANP

Pathological grading	Scores
Edema
Absent	0
Focal expansion of interlobular septae	1
Same as 1 + diffuse expansion of interlobar;	2
septae/diffuse expansion of interlobar septae
Same as 2 + expansion of interacinar septae	3
Same as 3 + expansion of intercellular spaces	4
Inflammation and perivascular infiltrate (intralobular or perivascular leukocytes/HPF)
0-1	0
2-10	1
11-20	2
21-30	3
> 30 or microabscesses	4
Acinar necrosis (necrotic cells/HPF)
Absent	0
1-4	1
5-10	2
11-16	3
> 16	4
Hemorrhage and fat necrosis (focus)
Absent	0
1-2	1
3-4	2
5-6	3
> 7	4

HPF: High-power field; ANP: Acute necrotizing pancreatitis.

Table 2 CTX concentrations in serum and pancreatic tissue, and penetration ratio (C_P/C_S ×100%) in three groups (mean ± SD)

Group	n	CS (μg/mL)	CP (μg/g)	Penetration ratio (%)
Control group	20	98.9 ± 2.4	18.6 ± 1.7	19
ANP group	20	96.8 ± 2.2	4.4 ± 0.6b	5b
Treatment group	20	97.4 ± 3.0	6.4 ± 1.7ab	7ab

^aP < 0.05 vs ANP group;

^bP < 0.001 vs control group. CTX: Cefotaxime.