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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Aug 21, 2009; 15(31): 3865-3873
Published online Aug 21, 2009. doi: 10.3748/wjg.15.3865
Published online Aug 21, 2009. doi: 10.3748/wjg.15.3865
Table 1 Correlation between laminin γ2 staining and clinicopathologic factors n (%)
| Case (n = 61) | Laminin γ2 | P value | ||
| Positive (n = 35) | Negative (n = 26) | |||
| Age (yr) | ||||
| ≤ 65 | 25 (41) | 15 (60) | 10 (40) | |
| > 65 | 36 (59) | 20 (56) | 16 (44) | 0.47 |
| Gender | ||||
| Male | 41 (67) | 25 (61) | 16 (39) | |
| Female | 20 (33) | 10 (50) | 10 (50) | 0.29 |
| Location | ||||
| Bile duct | 30 (49) | 20 (67) | 10 (33) | |
| Gall bladder | 18 (30) | 9 (50) | 9 (50) | |
| Ampulla of Vater | 13 (21) | 6 (46) | 7 (54) | 0.34 |
| Maximum diameter (mm) | ||||
| < 30 | 41 (67) | 25 (61) | 16 (39) | |
| ≥ 30 | 20 (33) | 10 (50) | 10 (50) | 0.29 |
| Histologic type | ||||
| Tub1 & pap | 35 (57) | 16 (46) | 19 (54) | |
| Others | 26 (43) | 19 (73) | 7 (27) | 0.03 |
| Depth | ||||
| Serosa negative | 37 (61) | 17 (46) | 20 (54) | |
| Serosa positive | 24 (39) | 18 (75) | 6 (25) | 0.02 |
| Lymph node metastasis | ||||
| Absent | 29 (48) | 16 (55) | 13 (45) | |
| Present | 27 (44) | 17 (63) | 10 (37) | 0.37 |
| Stage | ||||
| < IV | 43 (70) | 21 (49) | 22 (51) | |
| ≥ IV | 17 (28) | 13 (76) | 4 (24) | 0.046 |
Table 2 Correlation between parameters and the pattern of laminin β3 expression n (%)
| Total (n = 61) | Laminin β3 | P value | |||
| Invasive (n = 23) | Diffuse (n = 17) | Negative (n = 21) | |||
| Age (yr) | |||||
| ≤ 65 | 25 (41) | 9 (36) | 8 (32) | 8 (32) | |
| > 65 | 36 (59) | 14 (39) | 9 (25) | 13 (36) | 0.83 |
| Gender | |||||
| Male | 41 (67) | 17 (41) | 8 (20) | 16 (39) | |
| Female | 20 (33) | 6 (30) | 9 (45) | 5 (25) | 0.11 |
| Location | |||||
| Bile duct | 30 (49) | 14 (47) | 5 (17) | 11 (37) | |
| Gall bladder | 18 (30) | 5 (28) | 7 (39) | 6 (33) | |
| Ampulla of Vater | 13 (21) | 4 (31) | 5 (38) | 4 (31) | 0.40 |
| Maximum diameter (mm) | |||||
| < 30 | 40 (66) | 18 (45) | 10 (25) | 12 (30) | |
| ≥ 30 | 21 (34) | 5 (24) | 7 (33) | 9 (43) | 0.27 |
| Histologic type | |||||
| Tub1 & pap | 35 (57) | 9 (26) | 14 (40) | 12 (34) | |
| Others | 26 (43) | 14 (54) | 3 (12) | 9 (35) | 0.02 |
| Depth | |||||
| Serosa negative | 37 (61) | 11 (30) | 13 (35) | 13 (35) | |
| Serosa positive | 24 (39) | 12 (50) | 4 (17) | 8 (33) | 0.18 |
| Lymph node metastasis | |||||
| Absent | 29 (48) | 8 (28) | 11 (38) | 10 (34) | |
| Present | 27 (44) | 14 (52) | 5 (19) | 8 (30) | 0.13 |
| Stage | |||||
| < IV | 43 (70) | 10 (23) | 15 (35) | 18 (42) | |
| ≥ IV | 17 (28) | 12 (71) | 2 (12) | 3 (18) | 0.003 |
Table 3 Correlation between MMP7 staining and clinicopathologic factors n (%)
| Case (n = 61) | MMP7 | P value | ||
| Positive (n = 42) | Negative (n = 19) | |||
| Age (yr) | ||||
| ≤ 65 | 25 (42) | 17 (68) | 8 (32) | |
| > 65 | 36 (58) | 25 (69) | 11 (31) | 0.66 |
| Gender | ||||
| Male | 41 (67) | 30 (73) | 11 (27) | |
| Female | 20 (33) | 12 (60) | 8 (40) | 0.23 |
| Location | ||||
| Bile duct | 30 (49) | 24 (80) | 6 (20) | |
| Gall bladder | 18 (30) | 9 (50) | 9 (50) | |
| Ampulla of Vater | 13 (21) | 9 (69) | 4 (31) | 0.09 |
| Maximum diameter (mm) | ||||
| < 30 | 41 (67) | 29 (71) | 12 (29) | |
| ≥ 30 | 20 (33) | 13 (65) | 7 (35) | 0.43 |
| Histologic type | ||||
| Tub1 & pap | 35 (57) | 23 (66) | 12 (34) | |
| Others | 26 (43) | 19 (73) | 7 (27) | 0.37 |
| Depth | ||||
| Serosa negative | 37 (61) | 25 (68) | 12 (32) | |
| Serosa positive | 24 (39) | 17 (71) | 7 (29) | 0.58 |
| Lymph node metastasis | ||||
| Absent | 29 (48) | 21 (72) | 8 (28) | |
| Present | 27 (44) | 18 (67) | 9 (33) | 0.43 |
| Stage | ||||
| < IV | 43 (70) | 31 (72) | 12 (28) | |
| ≥ IV | 17 (28) | 10 (59) | 7 (41) | 0.24 |
Table 4 Expression of laminin γ2 and MMP7 in biliary tract carcinoma n (%)
| MMP7 expression | Laminin γ2 | P value | |
| Positive (n = 42) | Negative (n = 19) | ||
| Positive (n = 34) | 28 (46) | 6 (10) | |
| Negative (n = 27) | 14 (23) | 13 (21) | 0.01 |
Table 5 Expression of laminin β3 and MMP7 in biliary tract carcinoma n (%)
| MMP7 expression | Laminin β3 | P value | ||
| Invasive (n = 23) | Diffuse (n = 17) | Negative (n = 21) | ||
| Positive (n = 34) | 17 (28) | 6 (10) | 14 (23) | |
| Negative (n = 27) | 6 (10) | 11 (18) | 7 (11) | 0.037 |
Table 6 Expression of laminin β3 and laminin γ2 in biliary tract carcinoma n (%)
| Laminin γ2 expression | Laminin β3 | P value | ||
| Invasive (n = 23) | Diffuse (n = 17) | Negative (n = 21) | ||
| Positive (n = 42) | 18 (30) | 8 (13) | 9 (15) | |
| Negative (n = 19) | 5 (8) | 9 (15) | 12 (20) | 0.036 |
- Citation: Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y. Overexpression of β3/γ2 chains of laminin-5 and MMP7 in biliary cancer. World J Gastroenterol 2009; 15(31): 3865-3873
- URL: https://www.wjgnet.com/1007-9327/full/v15/i31/3865.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.3865