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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Aug 14, 2009; 15(30): 3793-3798
Published online Aug 14, 2009. doi: 10.3748/wjg.15.3793
Published online Aug 14, 2009. doi: 10.3748/wjg.15.3793
Table 1 Demographic details of patients and tumor characteristics
PRT n = 103 | Control n = 222 | P value | |
Sex | |||
Male | 62 | 130 | 0.875 |
Female | 41 | 92 | |
Age (yr)1 | 56 (52-61) | 57 (53-64) | 0.232 |
Distance of tumor from anal verge | |||
< 5 cm | 35 | 53 | 0.061 |
5-12 cm | 68 | 169 | |
Surgery | |||
APR | 27 | 55 | 0.564 |
LAR | 71 | 161 | |
CR | 5 | 6 | |
Preoperative serum CEA level | |||
Normal | 52 | 121 | 0.691 |
Abnormal | 35 | 65 | |
Unknown | 16 | 36 | |
Pretreatment TNM stage (%) | |||
I (T1-2 N0) | 0 (0) | 43 (19.4) | < 0.01 |
IIA (T3 N0) | 25 (24.3) | 63 (28.4) | |
IIB (T4 N0) | 4 (3.9) | 5 (2.3) | |
IIIA (T1-2 N1) | 3 (2.9) | 8 (3.6) | |
IIIB (T3-4 N1) | 33 (32.0) | 43 (19.4) | |
IIIC (AnyT N2) | 38 (36.9) | 60 (27.0) | |
Pathologic TNM stage (%) | |||
I (T1-2 N0) | 35 (34.0) | 55 (24.8) | 0.377 |
IIA (T3 N0) | 27 (26.2) | 62 (27.9) | |
IIB (T4 N0) | 1 (1.0) | 1 (5.0) | |
IIIA (T1-2 N1) | 6 (5.8) | 7 (3.2) | |
IIIB (T3-4 N1) | 18 (17.5) | 45 (20.3) | |
IIIC (AnyT N2) | 16 (15.5) | 52 (23.4) | |
Histological differentiation (%) | |||
High | 4 (3.9) | 29 (13.1) | < 0.01 |
Moderate | 70 (68.0) | 156 (70.3) | |
Poor | 24 (23.3) | 27 (12.2) | |
Mucinous and signet | 5 (4.9) | 10 (4.5) | |
LVI (%) | |||
Present | 22 (21.4) | 58 (26.1) | 0.353 |
Absent | 81 (78.6) | 164 (73.9) | |
Disease progression (%) | |||
Local Recurrence | 6 (5.8) | 32 (14.4) | 0.025 |
Distant Metastasis | 22 (21.4) | 47 (21.2) | 0.969 |
Death | 24 (23.3) | 66 (29.7) | 0.228 |
Table 2 The relevance of LVI and pathologic factors
LVI | Positive rate (%) | P value | |||
Present | Absent | ||||
PRT | |||||
ypT | T1 | 1 | 5 | 16.7 | 0.592 |
T2 | 6 | 31 | 16.2 | ||
T3 | 14 | 44 | 24.1 | ||
T4 | 1 | 1 | 50.0 | ||
ypN | N0 | 9 | 54 | 14.3 | 0.057 |
N1 | 9 | 15 | 37.5 | ||
N2 | 4 | 12 | 25.0 | ||
Histological differentiation | High | 1 | 3 | 25.0 | 0.998 |
Moderate | 15 | 55 | 21.4 | ||
Poor | 5 | 19 | 20.8 | ||
Mucinous and signet | 1 | 4 | 21.0 | ||
Downstaging | Yes | 7 | 34 | 17.1 | 0.388 |
No | 15 | 47 | 24.2 | ||
Control | |||||
pT | T1 | 0 | 11 | 0 | < 0.01 |
T2 | 8 | 50 | 13.8 | ||
T3 | 49 | 98 | 33.3 | ||
T4 | 1 | 5 | 16.7 | ||
pN | N0 | 15 | 103 | 12.7 | < 0.01 |
N1 | 15 | 37 | 28.8 | ||
N2 | 28 | 24 | 53.8 | ||
Histological differentiation | High | 7 | 22 | 24.1 | 0.015 |
Moderate | 34 | 122 | 21.8 | ||
Poor | 11 | 16 | 40.7 | ||
Mucinous and signet | 6 | 4 | 60.0 |
Table 3 The association of LVI and prognosis
PRT | P | Control | P | ||||
Present | Absent | Present | Absent | ||||
Disease progression (%) | Yes | 10 (38.5) | 16 (61.5) | 0.014 | 32 (43.2) | 42 (56.8) | < 0.01 |
No | 12 (15.6) | 65 (84.4) | 26 (17.6) | 122 (82.4) | |||
5-year DFS rate | % | 54.5 (12/22) | 80.2 (65/81) | 0.020 | 44.8 (26/58) | 73.2 (120/164) | < 0.01 |
5-year OS rate | % | 54.5 (12/22) | 82.7 (67/81) | < 0.010 | 48.3 (28/58) | 78.0 (128/164) | < 0.01 |
Table 4 Multivariate analysis of OS by COX model (backward elimination)
Variable | Hazard ratio | 95% CI | P value |
Distance from anal verge | 0.540 | 0.346-0.845 | < 0.01 |
Serum CEA level | 1.334 | 1.027-1.732 | 0.031 |
pTNM stage | 1.347 | 1.198-1.514 | < 0.01 |
LVI | 0.450 | 0.292-0.692 | < 0.01 |
- Citation: Du CZ, Xue WC, Cai Y, Li M, Gu J. Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: A retrospective cohort study. World J Gastroenterol 2009; 15(30): 3793-3798
- URL: https://www.wjgnet.com/1007-9327/full/v15/i30/3793.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.3793