Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats

Table 1 Levels of serum HA, LN, type III precollagen (PC III) and type IV collagen (IV- C) in different groups

Group	n	PCIII (ng/mL)	IV-C (ng/mL)	LN (ng/mL)	HA (ng/mL)
N	11	31.77 ± 9.47	28.65 ± 5.29	28.74 ± 9.73	67.27 ± 15.21
F	15	51.11 ± 11.86b	48.29 ± 8.93b	47.56 ± 17.65b	92.62 ± 18.61b
Co	17	43.10 ± 8.91a	41.04 ± 8.19a	38.54 ± 7.39a	79.88 ± 13.65a

N group: Normal control group; F group: Liver fibrosis group; Co group: CoPP group.

^aP < 0.05 vs liver fibrosis group;

^bP < 0.01 vs normal control group.

Table 2 Pathological grading of rat fibrous tissue

Group	n	-	+	++	+++
HE staining
N	11	11	0	0	0
F	15	0	8	7	0
Co	17	0	15	2	0
Foot staining
N	11	11	0	0	0
F	15	0	4	8	3
Co	17	0	10	7	0
VG staining
N	11	11	0	0	0
F	15	0	7	6	2
Co	17	0	14	3	0

Table 3 Levels of serum ALT and AST in different groups

Group	No.	ALT (U/L)	AST (U/L)
N	11	52.55 ± 9.36	176.45 ± 11.48
F	15	70.40 ± 12.30b	210.27 ± 11.50b
Co	17	60.82 ± 8.59a	194.53 ± 11.98a

^aP < 0.05 vs CoPP group,

^bP < 0.01 vs normal control group.