Clinical applications of hepatocyte transplantation

Table 1 Adult HT in metabolic liver disorders

	Patients (n = 27)	Range of viable1 cells number	Outcome (died/LT)	References
Urea cycle (OTC/ASL/ASS: 5/1/1)	7	1.9-4 × 109	1/4	[27–10]
Crigler-Najjar type 1	6	1.5-7.5 × 109	-/3	[11–14]
Hyper-cholesterolemia	5	1.0-3.2 × 109	-/-	[15]
Factor VII deficiency	3	1.1-2.2 × 109	-/2	[1116]
Others	62	3.2-7.5 × 109	-/3	[11171820]

¹In a few cases several cell infusions were performed; in one patient up to 18 infusions;

²Glycogenosis type 1 (n = 2); refsum disease (n = 1); progressive familial intra-hepatic cholestasis (n = 2); α-1-antitrypsine deficiency (n = 1).

Table 2 Adult hepatocyte transplantation in chronic and fulminant hepatic failure

	Patients	Viable cells range	Outcome died/alive/LT	References
Chronic liver diseases	20
Autotransplant	10	1.7 × 107-6.0 × 108	/	[19]
Allotransplant	10		4/6/3
Alcohol	5	/	2/3/-	[20]
α-1-antitrypsine deficiency	1	2.2 × 107	-/1/1	[4]
HCV related	1	7.5 × 106	1/-/-	[4]
Other	31	5 × 108-2 × 109	1/2/2	[2122]
FHF	22		13/9/7
Viral (HSV, HBV)	6	1.2 × 108-3 × 1010	3/3/2	[42023]
Drug-related	10	2.8 × 107-3.9 × 1010	8/2/2	[413202223]
Idiopathic	4	1.8 × 108- 4 × 109	1/3/3	[2022]
Other	22	1.7 × 108- 4.9 × 108	1/1/-	[120]

¹Cryptogenic cirrhosis (n = 1); idiopathic fibrosis (n = 1); liver transplant recipient (n = 1);

²Mushroom poisoning (n = 1); trisegmentectomy (n = 1).