Effect of 5-FU on modulation of disarrangement of immune-associated cytokines in experimental acute pancreatitis

Table 1 Change of level of pro-inflammatory cytokines in serum

Group	IL-1 (ng/mL)	IL-6 (IU/mL)	TNF (IU/mL)
A	0.28 ± 0.06	34.5 ± 6.40	11.82 ± 1.87
B  (2 h)	1.02 ± 0.121	98.83 ± 12.431	43.67 ± 5.721
(6 h)	1.13 ± 0.171	101.0 ± 15.071	48.67 ± 5.321
(24 h)	1.15 ± 0.131	127.17 ± 13.911	55.33 ± 12.791
C (2 h)	0.80 ± 0.0712	76.33 ± 7.4212	35.33 ± 4.501
(6 h)	0.70 ± 0.0612	74.33 ± 11.0212	31.17 ± 4.5412
(24 h)	1.02 ± 0.181	112.67 ± 20.061	42.33 ± 11.641

A: Sham operation Group without acute pancreatitis and drug injection; B: Acute pancreatitis Group; C: Acute pancreatitis with 5-FU group. 2 h, 6 h, 24 h: 2 h, 6 h, 24 h after operation.

¹Compared to sham operation Group (Group A), P < 0.05;

²Compared to pancreatitis Group (Group B), P < 0.05.

Table 2 Change of level of anti-inflammatory cytokines in serum

Group	IL-10 (pg/mL)	TGFβ(pg/mL)
A	22.05 ± 14.87	66.40 ± 13.20
B  (2 h)	36.52 ± 9.76	64.58 ± 10.56
(6 h)	37.75 ± 6.54	72.87 ± 18.34
(24 h)	68.13 ± 19.901	103.77 ± 28.951
C (2 h)	28.82 ± 6.63	61.15 ± 30.31
(6 h)	45.5 ± 4.721	80.27 ± 19.83
(24 h)	24.0 ± 7.862	68.52 ± 11.512

¹Compared to sham operation Group (Group A), P < 0.05;

²Compared to pancreatitis Group (Group B), P < 0.05.

Table 3 Change of index of severity of acute pancreatitis

Group	Amylase (U/L)	W.Weight of P (g)	W.B.C (×109/L)2	Neutrophils (%)
A	374.20 ± 92.84	0.51 ± 0.90	6.69 ± 2.59	0.35 ± 0.09
B  (2 h)	371.25 ± 86.28	1.63 ± 0.541	7.59 ± 2.25	0.74 ± 0.381
(6 h)	508.83 ± 344.82	1.85 ± 0.251	9.46 ± 2.16	0.75 ± 0.081
(24 h)	1817.25 ± 459.351	1.30 ± 0.131	6.93 ± 0.67	0.62 ± 0.111
C (2 h)	352.2 ± 118.15	0.87 ± 0.222	7.90 ± 2.33	0.48 ± 0.092
(6 h)	434.4 ± 138.35	0.68 ± 0.242	10.72 ± 1.45	0.69 ± 0.06
(24 h)	794.40 ± 225.9912	0.88 ± 0.1312	6.10 ± 1.44	0.53 ± 0.10

W.Weight of P: wet weight of pancreatic tissue.

¹Compared to sham operation Group (Group A), P < 0.05;

²Compared to pancreatitis Group (Group B), P < 0.05.