Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma

Table 1 Clinicopathological features of hepatocellular carcinoma patients

Patients and tissue specimens	n
Sex
Male	36
Female	6
Viral status
HBs-Ag positive	35
HBs-Ag negative	7
Histology of noncancerous liver tissues
Histologically normal	18
Liver cirrhosis	24
Tumor differentiation
Well differentiated	0
Moderately differentiated	22
Poorly differentiated	20
Total	42

Table 2 Relationship between DNMT1 and pathological change in patients with HCC n (%), χ² test

		DNMT1 expression (P/OR: up-regulated/normal + down-regulated)
	Subtotal	Up-regulated	Normal	Down-regulated	P	OR (95% CI)
Total or subtotal	42 (100.00)	17 (40.48)	13 (30.95)	12 (28.57)
Age (yr)					0.54	1.49 (0.41-5.35)
> 50	15 (35.71)	7 (46.67)	4 (26.67)	4 (26.67)
< 50	27 (64.29)	10 (37.04)	9 (33.33)	8 (29.63)
Size of tumor (cm)					0.23	0.45 (0.12-1.67)
> 5	17 (40.48)	5 (29.41)	6 (35.29)	6 (35.29)
< 5	25 (59.52)	12 (48.00)	7 (28.00)	6 (24.00)
Histological differentiation					0.014	0.20 (0.05-0.75)
Moderate	22 (52.38 )	5 (22.72)	9 (40.91)	8 (36.37)
Poor	20 (47.62)	12 (60.00)	4 (20.00)	4 (20.00)
HBsAg					0.169	4.5 (0.829-24.4)
Positive	35 (83.33)	15 (42.86)	12 (34.28)	8 (22.86)
Negative	7 (16.67)	2 (28.57)	1 (14.29)	4 (57.14)
Hepatocirrhosis					0.083	3.57 (0.81-15.71)
With	24 (57.14)	10 (41.67)	10 (41.67)	4 (16.67)
Without	18 (42.86)	3 (16.67)	7 (38.89)	8 (44.44)