Histological and biochemical alterations in early-stage lobar ischemia-reperfusion in rat liver

Table 1 Data analysis of different biochemical tests obtained from livers subjected to 60 min ischemia followed by 30-120 min reperfusion

Time of sampling	Glucose (&mgr;g/dL)	Urea (&mgr;g/dL)	Creatinine (&mgr;g/dL)	AST (IU/L)	ALT (IU/L)	LDH (IU/L)
Before ischemia	261.33 ± 36.16	17.66 ± 2.88	0.55 ± 0.058	54.82 ± 19.82	78.2 ± 24.3	153.75 ± 0.11
	n = 5	n = 5	n = 5	n = 5	n = 5	n = 16
During ischemia	189.66 ± 18.8	18.33 ± 1.2	0.57 ± 0.075	12.74 ± 9.51	18.19 ± 4.39	39.69 ± 8.58
	n = 5	n = 5	n = 7	n = 5	n = 5	n = 16
After reperfusion	160.83 ± 10.63	26.50 ± 1.66	2.62 ± 1.29	61.58 ± 9.12	142.28 ± 30.94	200.52 ± 60.52
	n = 14	n = 14	n = 13	n = 10	n = 7	n = 23

The values are expressed as the mean ± SE taken from at least 12 samples in test.

Table 2 Comparison of data obtained from biochemical analysis of blood samples taken from the animals exposed to 60 min ischemia followed by different times of reperfusion

	P-value
Sampling phase	Glucose	Urea	Creatinine	AST	ALT	LDH
Before ischemia/ during ischemia	0.38	0.72	0.79	0.043	0.049	0.034
Before ischemia/ after reperfusion	0.31	0.05a	0.006a	0.08	0.043a	0.008a
During ischemia/ after reperfusion	0.17	0.05a	0.05a	0.08	0.005a	0.014a

^aP < 0.05.