Brief Articles
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Mar 28, 2009; 15(12): 1480-1486
Published online Mar 28, 2009. doi: 10.3748/wjg.15.1480
Table 1 Distribution of mutations in different loops of domain III in SVR compared with BT patients
MutationPositionRegionNo. of patients
Effect on ΔG (kcal/mol)
SVR (n = 14)BT-PreT (n = 5)BT Post-T (n = 5)
C-T148Junction joining stem-loop IIIa b, c & d--1Increased
G-T158Loop IIIa-14Increased
T-A175Loop IIIb1--No effect
G & A ins1792--Increased
T ins.1801--Increased
T ins.1811--Increased
C-T186--1No effect
TTT-GGG194-196-1-No effect
C ins.2051--No effect
T-C199--1No effect
G-A243Junction joining stem-loop IIIa, b, c & d514No effect
C-T254Loop IIId-11Decreased
G ins.270-11Decreased
Table 2 Distribution of the 19 identified mutations in different loops of domain III in SVR and BT patients
RegionResponder (SVR; %)BT pre treatment (%)BT post treatment (%)
Stem-loop IIIa (156-171)-14.310
Stem-loop IIIb (172-227)5014.320
Stem-loop IIIc (228-238)---
Stem-loop IIId (253-279)4057.150
Junction joining stem-loop IIIa, b, c, & d (141-153) & (239-252)1014.320